| http://purl.uniprot.org/citations/16617102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16617102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16617102 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we define a function of metastasis-associated protein 1 (MTA1), a presumed corepressor of estrogen receptor alpha (ERalpha), as a transcriptional activator of Breast Cancer Amplified Sequence 3 (BCAS3), a gene amplified and overexpressed in breast cancers. We identified BCAS3 as a MTA1 chromatin target in a functional genomic screen. MTA1 stimulation of BCAS3 transcription required ERalpha and involved a functional ERE half-site in BCAS3. Furthermore, we discovered that MTA1 is acetylated on lysine 626, and that this acetylation is necessary for a productive transcriptional recruitment of RNA polymerase II complex to the BCAS3 enhancer sequence. BCAS3 expression was elevated in mammary tumors from MTA1 transgenic mice and 60% of the human breast tumors, and correlated with the coexpression of MTA1 as well as with tumor grade and proliferation of primary breast tumor samples. These findings reveal a previously unrecognized function of MTA1 in stimulating BCAS3 expression and suggest an important role for MTA1-BCAS3 pathway in promoting cancerous phenotypes in breast tumor cells."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0601989103"xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0601989103"xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Kumar R."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Kumar R."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Holm C."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Holm C."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Balasenthil S."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Balasenthil S."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Gururaj A.E."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Gururaj A.E."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Landberg G."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Landberg G."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Rayala S.K."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Rayala S.K."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Singh R.R."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Singh R.R."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Talukder A.H."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "Talukder A.H."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "den Hollander P."xsd:string |
| http://purl.uniprot.org/citations/16617102 | http://purl.uniprot.org/core/author | "den Hollander P."xsd:string |