| http://purl.uniprot.org/citations/16618798 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16618798 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16618798 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated the role of SIRT7, one of the seven members of the mammalian sirtuin family. We show that SIRT7 is a widely expressed nucleolar protein that is associated with active rRNA genes (rDNA), where it interacts with RNA polymerase I (Pol I) as well as with histones. Overexpression of SIRT7 increases Pol I-mediated transcription, whereas knockdown of SIRT7 or inhibition of the catalytic activity results in decreased association of Pol I with rDNA and a reduction of Pol I transcription. Depletion of SIRT7 stops cell proliferation and triggers apoptosis. Our findings suggest that SIRT7 is a positive regulator of Pol I transcription and is required for cell viability in mammals."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1399706"xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1399706"xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/author | "Guarente L."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/author | "Guarente L."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/author | "Grummt I."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/author | "Grummt I."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/author | "Voit R."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/author | "Voit R."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/author | "Ford E."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/author | "Ford E."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/author | "Magin C."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/author | "Magin C."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/author | "Liszt G."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/author | "Liszt G."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/pages | "1075-1080"xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/pages | "1075-1080"xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/title | "Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription."xsd:string |
| http://purl.uniprot.org/citations/16618798 | http://purl.uniprot.org/core/title | "Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription."xsd:string |