| http://purl.uniprot.org/citations/16618808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16618808 | http://www.w3.org/2000/01/rdf-schema#comment | "Notch signaling promotes commitment of keratinocytes to differentiation and suppresses tumorigenesis. p63, a p53 family member, has been implicated in establishment of the keratinocyte cell fate and/or maintenance of epithelial self-renewal. Here we show that p63 expression is suppressed by Notch1 activation in both mouse and human keratinocytes through a mechanism independent of cell cycle withdrawal and requiring down-modulation of selected interferon-responsive genes, including IRF7 and/or IRF3. In turn, elevated p63 expression counteracts the ability of Notch1 to restrict growth and promote differentiation. p63 functions as a selective modulator of Notch1-dependent transcription and function, with the Hes-1 gene as one of its direct negative targets. Thus, a complex cross-talk between Notch and p63 is involved in the balance between keratinocyte self-renewal and differentiation."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1406006"xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/author | "Della Gatta G."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/author | "Roop D.R."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/author | "Kitajewski J."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/author | "Mandinova A."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/author | "Missero C."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/author | "Dotto G.P."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/author | "Tommasi di Vignano A."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/author | "Antonini D."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/author | "Koster M.I."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/author | "Chiorino G."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/author | "Nguyen B.C."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/author | "Devgan V."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/author | "Lefort K."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/pages | "1028-1042"xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/title | "Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation."xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/16618808 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16618808 |
| http://purl.uniprot.org/citations/16618808 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16618808 |