| http://purl.uniprot.org/citations/16619302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16619302 | http://www.w3.org/2000/01/rdf-schema#comment | "The glucocorticoid receptor (GR) acts as a ligand dependent transcription factor but can also cross talk with other signaling pathways via protein-protein interactions. In this paper we describe methods to study novel cytosolic GR interacting proteins, using mAb based immunoaffinity chromatography of GR from rat liver cytosol. Co-purifying proteins were identified by 2-DE in combination with MALDI-TOF-MS. Non-liganded/non-activated and in vitro liganded/activated GR, respectively, co-purifies with specific sets of proteins. Of these 34 were conclusively identified, seven have previously been reported to be part of the GR-complex, revealing 27 new possible interacting candidates for the GR-complex. Of the novel GR interacting proteins the major vault protein, TATA binding interacting protein 49a and glycoprotein PP63 were of special interest. Furthermore, using 2-D DIGE we show that the set of proteins interacting with non-liganded GR is distinctly different in protein amount compared to the proteins found with liganded/activated GR. This suggests the presence of different GR complexes in the cell, which was further substantiated by the finding of several separate GR native protein complexes, "GR-receptosomes", using blue native gel electrophoresis. Our findings suggest the existence of several new mechanisms for GR signaling and regulation."xsd:string |
| http://purl.uniprot.org/citations/16619302 | http://purl.org/dc/terms/identifier | "doi:10.1002/pmic.200500266"xsd:string |
| http://purl.uniprot.org/citations/16619302 | http://purl.uniprot.org/core/author | "Gustafsson J.A."xsd:string |
| http://purl.uniprot.org/citations/16619302 | http://purl.uniprot.org/core/author | "Schroder W.P."xsd:string |
| http://purl.uniprot.org/citations/16619302 | http://purl.uniprot.org/core/author | "Hedman E."xsd:string |
| http://purl.uniprot.org/citations/16619302 | http://purl.uniprot.org/core/author | "Asadi A."xsd:string |
| http://purl.uniprot.org/citations/16619302 | http://purl.uniprot.org/core/author | "Widen C."xsd:string |
| http://purl.uniprot.org/citations/16619302 | http://purl.uniprot.org/core/author | "Wikstrom A.C."xsd:string |
| http://purl.uniprot.org/citations/16619302 | http://purl.uniprot.org/core/author | "Dinnetz I."xsd:string |
| http://purl.uniprot.org/citations/16619302 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16619302 | http://purl.uniprot.org/core/name | "Proteomics"xsd:string |
| http://purl.uniprot.org/citations/16619302 | http://purl.uniprot.org/core/pages | "3114-3126"xsd:string |
| http://purl.uniprot.org/citations/16619302 | http://purl.uniprot.org/core/title | "Proteomic identification of glucocorticoid receptor interacting proteins."xsd:string |
| http://purl.uniprot.org/citations/16619302 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/16619302 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16619302 |
| http://purl.uniprot.org/citations/16619302 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16619302 |
| http://purl.uniprot.org/uniprot/#_E9PT44-mappedCitation-16619302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16619302 |
| http://purl.uniprot.org/uniprot/#_P63036-mappedCitation-16619302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16619302 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A088-mappedCitation-16619302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16619302 |
| http://purl.uniprot.org/uniprot/#_A0A140TAE0-mappedCitation-16619302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16619302 |
| http://purl.uniprot.org/uniprot/#_O88801-mappedCitation-16619302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16619302 |
| http://purl.uniprot.org/uniprot/#_P62870-mappedCitation-16619302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16619302 |
| http://purl.uniprot.org/uniprot/#_Q63716-mappedCitation-16619302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16619302 |
| http://purl.uniprot.org/uniprot/#_P24090-mappedCitation-16619302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16619302 |