| http://purl.uniprot.org/citations/16621999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16621999 | http://www.w3.org/2000/01/rdf-schema#comment | "CD72, a 45-kDa type II transmembrane glycoprotein carrying an ITIM motif, is believed to be an inhibitory coreceptor of the BCR. Mature B cells lacking CD72 show enhanced Ca(2+) mobilization and are hyperproliferative in response to BCR ligation. However, the signal transduction pathways downstream of BCR signaling that transmit the inhibitory effect of CD72 in mature B cells remain unknown. To address this question, we used hen egg lysozyme-specific BCR transgenic mice to elucidate the differential cell signaling between wild-type and CD72-deficient B cells in response to hen egg lysozyme Ag stimulation. Our results demonstrate that CD72 predominantly down-regulates the major signal transduction pathways downstream of the BCR, including NF-AT, NF-kappaB, ERK, JNK, p38-MAPK, and PI3K/Akt in mature B cells. CD72 ligation with anti-CD72 Ab (K10.6), which mimics the binding of CD100 (a natural ligand for CD72) to release the inhibitory function of CD72, augments cell proliferation, Ca(2+) flux, IkappaBalpha activation, and ERK MAPK activity upon Ag stimulation in wild-type B cells. In addition, we show direct evidence that CD72 promotes cell cycle arrest and apoptosis after Ag stimulation in mature B cells. Taken together, our findings conclude that CD72 plays a dominant role as a negative regulator of BCR signaling in primary mature B lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/16621999 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.176.9.5321"xsd:string |
| http://purl.uniprot.org/citations/16621999 | http://purl.uniprot.org/core/author | "Tung J.W."xsd:string |
| http://purl.uniprot.org/citations/16621999 | http://purl.uniprot.org/core/author | "Li D.H."xsd:string |
| http://purl.uniprot.org/citations/16621999 | http://purl.uniprot.org/core/author | "Parnes J.R."xsd:string |
| http://purl.uniprot.org/citations/16621999 | http://purl.uniprot.org/core/author | "Snow A.L."xsd:string |
| http://purl.uniprot.org/citations/16621999 | http://purl.uniprot.org/core/author | "Martinez O.M."xsd:string |
| http://purl.uniprot.org/citations/16621999 | http://purl.uniprot.org/core/author | "Ngernmaneepothong R."xsd:string |
| http://purl.uniprot.org/citations/16621999 | http://purl.uniprot.org/core/author | "Tarner I.H."xsd:string |
| http://purl.uniprot.org/citations/16621999 | http://purl.uniprot.org/core/author | "Yukinari T."xsd:string |
| http://purl.uniprot.org/citations/16621999 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16621999 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16621999 | http://purl.uniprot.org/core/pages | "5321-5328"xsd:string |
| http://purl.uniprot.org/citations/16621999 | http://purl.uniprot.org/core/title | "CD72 down-modulates BCR-induced signal transduction and diminishes survival in primary mature B lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/16621999 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/16621999 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16621999 |
| http://purl.uniprot.org/citations/16621999 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16621999 |
| http://purl.uniprot.org/uniprot/#_A2AIN5-mappedCitation-16621999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16621999 |
| http://purl.uniprot.org/uniprot/#_Q3UNJ0-mappedCitation-16621999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16621999 |
| http://purl.uniprot.org/uniprot/#_Q99L55-mappedCitation-16621999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16621999 |
| http://purl.uniprot.org/uniprot/#_P21855-mappedCitation-16621999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16621999 |
| http://purl.uniprot.org/uniprot/#_Q3UZ35-mappedCitation-16621999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16621999 |
| http://purl.uniprot.org/uniprot/#_Q3UB58-mappedCitation-16621999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16621999 |
| http://purl.uniprot.org/uniprot/#_Q8CIX9-mappedCitation-16621999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16621999 |