| http://purl.uniprot.org/citations/16622419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16622419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16622419 | http://www.w3.org/2000/01/rdf-schema#comment | "The basic element for chromosome inheritance, the centromere, is epigenetically determined in mammals. The prime candidate for specifying centromere identity is the array of nucleosomes assembled with CENP-A, the centromere-specific histone H3 variant. Here, we show that CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of three new human centromere proteins (CENP-M, CENP-N and CENP-T), along with CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Facilitates chromatin transcription (FACT) and nucleophosmin-1 (previously implicated in transcriptional chromatin remodelling and as a multifunctional nuclear chaperone, respectively) are absent from histone H3-containing nucleosomes, but are stably recruited to CENP-A nucleosomes independent of CENP-A NAC. Seven new CENP-A-nucleosome distal (CAD) centromere components (CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) are identified as assembling on the CENP-A NAC. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling."xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1397"xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1397"xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/author | "Bailey A.O."xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/author | "Bailey A.O."xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/author | "Black B.E."xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/author | "Black B.E."xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/author | "Cleveland D.W."xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/author | "Cleveland D.W."xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/author | "Foltz D.R."xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/author | "Foltz D.R."xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/author | "Jansen L.E.T."xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/author | "Jansen L.E.T."xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/pages | "458-469"xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/pages | "458-469"xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/title | "The human CENP-A centromeric nucleosome-associated complex."xsd:string |
| http://purl.uniprot.org/citations/16622419 | http://purl.uniprot.org/core/title | "The human CENP-A centromeric nucleosome-associated complex."xsd:string |