| http://purl.uniprot.org/citations/16622420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16622420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16622420 | http://www.w3.org/2000/01/rdf-schema#comment | "In vertebrates, centromeres lack defined sequences and are thought to be propagated by epigenetic mechanisms involving the incorporation of specialized nucleosomes containing the histone H3 variant centromere protein (CENP)-A. However, the precise mechanisms that target CENP-A to centromeres remain poorly understood. Here, we isolated a multi-subunit complex, which includes the established inner kinetochore components CENP-H and CENP-I, and nine other proteins, from both human and chicken cells. Our analysis of these proteins demonstrates that the CENP-H-I complex can be divided into three functional sub-complexes, each of which is required for faithful chromosome segregation. Interestingly, newly expressed CENP-A is not efficiently incorporated into centromeres in knockout mutants of a subclass of CENP-H-I complex proteins, indicating that the CENP-H-I complex may function, in part, as a marker directing CENP-A deposition to centromeres."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1396"xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1396"xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "Desai A."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "Desai A."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "Okada M."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "Okada M."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "Hori T."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "Hori T."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "McLeod I.X."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "McLeod I.X."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "Cheeseman I.M."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "Cheeseman I.M."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "Fukagawa T."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "Fukagawa T."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "Okawa K."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/author | "Okawa K."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/16622420 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |