| http://purl.uniprot.org/citations/1662392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1662392 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 6 (IL-6) signal is transduced through gp130 that associates with a complex of IL-6 and IL-6 receptor. Truncations or amino acid substitutions offe introduced in the cytoplasmic region of human gp130, and the mutant cDNAs were transfected into murine interleukin 3-dependent cells to determine amino acid residues critical for generating the IL-6-mediated growth signal. In the 277-amino acid cytoplasmic region of gp130, a 61-amino acid region proximal to the transmembrane domain was sufficient for generating the growth signal. In this region, two short segments were significantly homologous with other cytokine-receptor family members. One segment is conserved in almost all members of the family, and the other is found especially in granulocyte colony-stimulating factor receptor, interleukin 2 receptor beta chain, erythropoietin receptor, KH97 (a granulocyte/macrophage colony-stimulating factor receptor-associated molecule), and interleukin 3 receptor. gp130 molecules with mutations in either of these two segments could not transduce growth signal. Loss of signal-transducing ability of gp130 with such a mutation coincided with disappearance of IL-6-induced tyrosine phosphorylation of gp130."xsd:string |
| http://purl.uniprot.org/citations/1662392 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.88.24.11349"xsd:string |
| http://purl.uniprot.org/citations/1662392 | http://purl.uniprot.org/core/author | "Kishimoto T."xsd:string |
| http://purl.uniprot.org/citations/1662392 | http://purl.uniprot.org/core/author | "Murakami M."xsd:string |
| http://purl.uniprot.org/citations/1662392 | http://purl.uniprot.org/core/author | "Hamaguchi M."xsd:string |
| http://purl.uniprot.org/citations/1662392 | http://purl.uniprot.org/core/author | "Hibi M."xsd:string |
| http://purl.uniprot.org/citations/1662392 | http://purl.uniprot.org/core/author | "Yasukawa K."xsd:string |
| http://purl.uniprot.org/citations/1662392 | http://purl.uniprot.org/core/author | "Taga T."xsd:string |
| http://purl.uniprot.org/citations/1662392 | http://purl.uniprot.org/core/author | "Narazaki M."xsd:string |
| http://purl.uniprot.org/citations/1662392 | http://purl.uniprot.org/core/author | "Yawata H."xsd:string |
| http://purl.uniprot.org/citations/1662392 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1662392 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/1662392 | http://purl.uniprot.org/core/pages | "11349-11353"xsd:string |
| http://purl.uniprot.org/citations/1662392 | http://purl.uniprot.org/core/title | "Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family."xsd:string |
| http://purl.uniprot.org/citations/1662392 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/1662392 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1662392 |
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| http://purl.uniprot.org/uniprot/P23458 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1662392 |
| http://purl.uniprot.org/uniprot/Q9UHF4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1662392 |