| http://purl.uniprot.org/citations/16623928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16623928 | http://www.w3.org/2000/01/rdf-schema#comment | "IgG-binding Fc receptors, and in particular FcgammaRIII, are crucial for induction of collagen-induced arthritis (CIA), as FcgammaRIII-deficient mice are highly protected to arthritis. However, which of the FcgammaRIII-expressing cells that is responsible for induction of arthritis is not known. In this study, we have addressed this question by purifying different FcgammaRIII(+) cell populations, transferred them to FcgammaRIII-deficient mice and studied if the recipient mice can develop arthritis. The cell populations were isolated from spleen, bone marrow and the peritoneal cavity. Our results show that FcgammaRIII(+) CD11b(+) peritoneal macrophages can render FcgammaRIII-deficient mice susceptible to CIA. In contrast, FcgammaRIII(-) peritoneal macrophages or FcgammaRIII(+) spleenocytes, bone marrow cells, mast cells or monocytes could not mediate this effect. To further evaluate the contribution of the FcgammaRIII(+) macrophages in arthritis, we investigated the cytokine profile in these cells during CIA. The arthritic macrophages exhibited significantly higher mRNA levels of TNFalpha and IL-12p35 compared with macrophages from normal mice. We conclude that FcgammaRIII-expressing macrophages, producing pro-inflammatory cytokine and T helper type 1 differentiating factor, are the major effector cells in the induction of CIA."xsd:string |
| http://purl.uniprot.org/citations/16623928 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-3083.2006.01743.x"xsd:string |
| http://purl.uniprot.org/citations/16623928 | http://purl.uniprot.org/core/author | "Xiang Z."xsd:string |
| http://purl.uniprot.org/citations/16623928 | http://purl.uniprot.org/core/author | "Nilsson G."xsd:string |
| http://purl.uniprot.org/citations/16623928 | http://purl.uniprot.org/core/author | "Andren M."xsd:string |
| http://purl.uniprot.org/citations/16623928 | http://purl.uniprot.org/core/author | "Kleinau S."xsd:string |
| http://purl.uniprot.org/citations/16623928 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16623928 | http://purl.uniprot.org/core/name | "Scand J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16623928 | http://purl.uniprot.org/core/pages | "282-289"xsd:string |
| http://purl.uniprot.org/citations/16623928 | http://purl.uniprot.org/core/title | "FcgammaRIII-expressing macrophages are essential for development of collagen-induced arthritis."xsd:string |
| http://purl.uniprot.org/citations/16623928 | http://purl.uniprot.org/core/volume | "63"xsd:string |
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