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| http://purl.uniprot.org/citations/16626647 | http://www.w3.org/2000/01/rdf-schema#comment | "The expression of the galanin receptor-1 and -2 (Gal(1) and Gal(2)) messenger ribonucleic acids (mRNAs) was studied in the lower spinal cord of rat by means of in situ hybridization, using ribonucleic acid probes (riboprobes). Naïve rats as well as rats with unilateral axotomy of the sciatic nerve or unilateral inflammation of the hindpaw were analyzed. In naïve rats, numerous Gal(1) mRNA-positive (+) neurons were detected in lamina (L) I-III. In addition, several Gal(1) mRNA(+) neurons were seen in deeper layers, including the ventral horns, area X, and the lateral spinal nucleus. In contrast, few and comparatively weakly labeled Gal(2) mRNA(+) neurons were observed, mostly in the ventral horns and in area X, with fewer in the dorsal horn and in the sympathetic and parasympathetic intermediate lateral cell columns. Axotomy induced a strong increase in intensity and number of Gal(2) mRNA(+) motoneurons ipsilateral to the lesion. In contrast, nerve cut or hindpaw inflammation did not alter the expression of Gal(1) or Gal(2) in the dorsal horn. The present (and previous) results suggest that galanin, acting through Gal(1) and Gal(2) receptors, has a modulatory role on spinal excitability, not only via interneurons in superficial dorsal horn, but also on neurons in deep layers and area X, as well as on the sympathetic and parasympathetic outflow. Furthermore, the nerve injury-induced Gal(2) upregulation in motor neurons suggests a role for galanin in survival/regeneration mechanisms."xsd:string |
| http://purl.uniprot.org/citations/16626647 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainres.2006.02.088"xsd:string |
| http://purl.uniprot.org/citations/16626647 | http://purl.uniprot.org/core/author | "Hokfelt T."xsd:string |
| http://purl.uniprot.org/citations/16626647 | http://purl.uniprot.org/core/author | "O'donnell D."xsd:string |
| http://purl.uniprot.org/citations/16626647 | http://purl.uniprot.org/core/author | "Mennicken F."xsd:string |
| http://purl.uniprot.org/citations/16626647 | http://purl.uniprot.org/core/author | "Brumovsky P."xsd:string |
| http://purl.uniprot.org/citations/16626647 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16626647 | http://purl.uniprot.org/core/name | "Brain Res"xsd:string |
| http://purl.uniprot.org/citations/16626647 | http://purl.uniprot.org/core/pages | "111-120"xsd:string |
| http://purl.uniprot.org/citations/16626647 | http://purl.uniprot.org/core/title | "Differential distribution and regulation of galanin receptors- 1 and -2 in the rat lumbar spinal cord."xsd:string |
| http://purl.uniprot.org/citations/16626647 | http://purl.uniprot.org/core/volume | "1085"xsd:string |
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