| http://purl.uniprot.org/citations/16627761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16627761 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 12 (IL-12) is a major inducer of interferon gamma (IFN-gamma) and the principal mediator of T helper 1 (Th1) differentiation. To identify IL-12-regulated genes, which might contribute to Th1 differentiation and IFNG regulation, we employed microarray analysis. Surprisingly, a ubiquitously expressed proprotein convertase (PC), furin, was one of the most consistently IL-12-induced genes in T cells, and among PCs was the only one regulated by this cytokine. Furin was preferentially expressed in differentiated Th1 cells in a Stat4-dependent manner. Expression of furin enhanced IFN-gamma secretion, whereas inhibition of furin interfered with IFN-gamma production. Thus, we conclude that IL-12 induction of furin might represent a new aspect of IFN-gamma regulation and control of Th1 differentiation."xsd:string |
| http://purl.uniprot.org/citations/16627761 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-09-3824"xsd:string |
| http://purl.uniprot.org/citations/16627761 | http://purl.uniprot.org/core/author | "Kanno Y."xsd:string |
| http://purl.uniprot.org/citations/16627761 | http://purl.uniprot.org/core/author | "O'Shea J.J."xsd:string |
| http://purl.uniprot.org/citations/16627761 | http://purl.uniprot.org/core/author | "Muul L."xsd:string |
| http://purl.uniprot.org/citations/16627761 | http://purl.uniprot.org/core/author | "Pesu M."xsd:string |
| http://purl.uniprot.org/citations/16627761 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16627761 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/16627761 | http://purl.uniprot.org/core/pages | "983-985"xsd:string |
| http://purl.uniprot.org/citations/16627761 | http://purl.uniprot.org/core/title | "Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma."xsd:string |
| http://purl.uniprot.org/citations/16627761 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/16627761 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16627761 |
| http://purl.uniprot.org/citations/16627761 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16627761 |
| http://purl.uniprot.org/uniprot/#_P09958-mappedCitation-16627761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16627761 |
| http://purl.uniprot.org/uniprot/P09958 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16627761 |