| http://purl.uniprot.org/citations/16628214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16628214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16628214 | http://www.w3.org/2000/01/rdf-schema#comment | "The BRCA1 tumour suppressor and its heterodimeric partner BARD1 constitute an E3-ubiquitin (Ub) ligase and function in DNA repair by unknown mechanisms. We show here that the Caenorhabditis elegans BRCA1/BARD1 (CeBCD) complex possesses an E3-Ub ligase responsible for ubiquitylation at DNA damage sites following ionizing radiation (IR). The DNA damage checkpoint promotes the association of the CeBCD complex with E2-Ub conjugating enzyme, Ubc5(LET-70), leading to the formation of an active E3-Ub ligase on chromatin following IR. Correspondingly, defects in Ubc5(let-70) or the DNA damage checkpoint genes atl-1 or mre-11 abolish CeBCD-dependent ubiquitylation in vivo. Extending these findings to human cells reveals a requirement for UbcH5c, the MRN complex, gamma-H2AX and a co-dependence for ATM and ATR kinases for BRCA1-dependent ubiquitylation at DNA damage sites. Furthermore, we demonstrate that the DNA damage checkpoint promotes the association between BRCA1 and UbcH5c to form an active E3-Ub ligase on chromatin after IR. These data reveal that BRCA1-dependent ubiquitylation is activated at sites of DNA repair by the checkpoint as part of a conserved DNA damage response."xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601102"xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601102"xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/author | "Polanowska J."xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/author | "Polanowska J."xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/author | "Boulton S.J."xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/author | "Boulton S.J."xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/author | "Garcia-Muse T."xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/author | "Garcia-Muse T."xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/author | "Martin J.S."xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/author | "Martin J.S."xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/author | "Petalcorin M.I.R."xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/author | "Petalcorin M.I.R."xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/pages | "2178-2188"xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/pages | "2178-2188"xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/title | "A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites."xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/title | "A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites."xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16628214 | http://purl.uniprot.org/core/volume | "25"xsd:string |