| http://purl.uniprot.org/citations/16630564 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16630564 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16630564 | http://www.w3.org/2000/01/rdf-schema#comment | "Surfactant protein-B (SP-B) and -C (SP-C) are small hydrophobic surfactant proteins that maintain surface tension in alveoli. Both SP-B and SP-C are regulated by a key factor, thyroid transcription factor-1 (TTF-1), in lung cells. Previously, we identified a 26-kDa, TTF-1-associated protein (TAP26) that was shown to interact with TTF-1 and enhance TTF-1-transactivated SP-B promoter activity. In this study, we hypothesized that TAP26 could also serve as a co-activator of the SP-C promoter. Using the chromatin immunoprecipitation assay (ChIP), we demonstrated that TAP26 was not only a component of the SP-B promoter, but was also a component of the SP-C promoter complex in lung cells. TAP26 could synergistically stimulate TTF-1-activated SP-B and SP-C promoter activities in H441 cells (a lung adenocarcinoma cell). However, in MLE12 cells (a murine lung type II cell), only SP-B, but not SP-C, promoter activity was improved by TAP26 in a concentration-dependent manner. This result indicated that the TTF-1/TAP26 complex-activated SP-C promoter activity was already optimized in MLE12 cells and that the response of the SP-C promoter to the complex was different from that of the SP-B promoter. Via promoter mutation analysis, adjacent TTF-1 binding sites within the proximal promoter region of SP-C were found to be essential for TTF-1/TAP26-enhanced SP-C promoter activity. Thus, a dimerized complex structure was needed for advanced promoter activity. This result also provided a molecular mechanism by which both the SP-B and SP-C promoters could be differentially regulated by the same complex."xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.03.158"xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.03.158"xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/author | "Liu C.-C."xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/author | "Liu C.-C."xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/author | "Yang Y.-S."xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/author | "Yang Y.-S."xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/author | "Weissler J.C."xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/author | "Weissler J.C."xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/author | "Yang M.-C."xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/author | "Yang M.-C."xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/pages | "484-490"xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/pages | "484-490"xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/title | "The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SFTPB) and -C (SFTPBC) promoters in lung cells."xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/title | "The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SFTPB) and -C (SFTPBC) promoters in lung cells."xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/volume | "344"xsd:string |
| http://purl.uniprot.org/citations/16630564 | http://purl.uniprot.org/core/volume | "344"xsd:string |