| http://purl.uniprot.org/citations/16630820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16630820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16630820 | http://www.w3.org/2000/01/rdf-schema#comment | "The Wnt pathway controls cell fates, tissue homeostasis, and cancer. Its activation entails the association of beta-catenin with nuclear TCF/LEF proteins and results in transcriptional activation of target genes. The mechanism by which nuclear beta-catenin controls transcription is largely unknown. Here we genetically identify a novel Wnt/Wg pathway component that mediates the transcriptional outputs of beta-catenin/Armadillo. We show that Drosophila Hyrax and its human ortholog, Parafibromin, components of the Polymerase-Associated Factor 1 (PAF1) complex, are required for nuclear transduction of the Wnt/Wg signal and bind directly to the C-terminal region of beta-catenin/Armadillo. Moreover, we find that the transactivation potential of Parafibromin/Hyrax depends on the recruitment of Pygopus to beta-catenin/Armadillo. Our results assign to the tumor suppressor Parafibromin an unexpected role in Wnt signaling and provide a molecular mechanism for Wnt target gene control, in which the nuclear Wnt signaling complex directly engages the PAF1 complex, thereby controlling transcriptional initiation and elongation by RNA Polymerase II."xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.01.053"xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.01.053"xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/author | "Basler K."xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/author | "Basler K."xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/author | "Hausmann G."xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/author | "Hausmann G."xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/author | "Mosimann C."xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/author | "Mosimann C."xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/pages | "327-341"xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/pages | "327-341"xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/title | "Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo."xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/title | "Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo."xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/16630820 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16630820 |
| http://purl.uniprot.org/citations/16630820 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16630820 |
| http://purl.uniprot.org/citations/16630820 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16630820 |
| http://purl.uniprot.org/citations/16630820 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16630820 |