| http://purl.uniprot.org/citations/16631158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16631158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16631158 | http://www.w3.org/2000/01/rdf-schema#comment | "Defects in some of liver-enriched genes in mammals will cause liver-and/or blood-related diseases. However, due to the fact that embryogenesis happens intrauterinally in the mammals, the function of these liver-enriched genes during liver organogenesis is poorly studied. We report here the identification of 129 genuine liver-enriched genes in adult zebrafish and show that, through in situ hybridization, 69 of these genes are also enriched in the embryonic liver. External embryogenesis coupled with the well-established morpholino-mediated gene knock-down technique in zebrafish offers us a unique opportunity to study if this group of genes plays any role during liver organogenesis in the future. As an example, preliminary study using morpholino-mediated gene knock-down method revealed that a novel liver-enriched gene leg1 is crucial for the liver expansion growth. We also report the analysis of promoter regions of 51 liver-enriched genes by searching putative binding sites for Hnf1, Hnf3, Hnf4 and Hnf6, four key transcription factors enriched in the liver. We found that promoter regions of majority of liver-enriched genes contain putative binding sites for more than one HNF factors, suggesting that most of liver-enriched genes are likely co-regulated by different combination of HNF factors. This observation supports the hypothesis that these four liver-enriched transcription factors form a network in controlling the expression of liver-specific or -enriched genes in the liver."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2006.03.018"xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/author | "Guo L."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/author | "Guo L."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/author | "Peng J."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/author | "Peng J."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/author | "Wu W."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/author | "Wu W."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/author | "Soo H.M."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/author | "Soo H.M."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/author | "Wen C."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/author | "Wen C."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/author | "Cheng W."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/author | "Cheng W."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/pages | "482-496"xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/pages | "482-496"xsd:string |
| http://purl.uniprot.org/citations/16631158 | http://purl.uniprot.org/core/title | "HNF factors form a network to regulate liver-enriched genes in zebrafish."xsd:string |