| http://purl.uniprot.org/citations/16632201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16632201 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in leucine-rich repeat kinase 2 gene (LRRK2) have been associated with idiopathic Parkinson's disease (PD), as well as pleomorphic neurodegenerative pathology, including Alzheimer's disease. One specific LRRK2 mutation, G2019S, was reported in 18% of people with PD of Ashkenazi descent, supporting a founder effect in this population. To determine if this mutation is also associated with dementia in the Ashkenazim, we screened 192 elderly Ashkenazi Jewish (AJ) individuals in a longitudinal aging and cognition study, of whom 49 (25.5%) had dementia. Two non-demented individuals harbored the mutation (2/143, 1.4%), but no individuals with dementia. Neither person with the mutation had Parkinson's disease. Therefore, the LRRK2 mutation has a relatively high frequency in the AJ population, is not fully penetrant for parkinsonism in the elderly, and does not appear to be commonly associated with late-onset dementia."xsd:string |
| http://purl.uniprot.org/citations/16632201 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neulet.2006.03.044"xsd:string |
| http://purl.uniprot.org/citations/16632201 | http://purl.uniprot.org/core/author | "Katz M."xsd:string |
| http://purl.uniprot.org/citations/16632201 | http://purl.uniprot.org/core/author | "Ozelius L.J."xsd:string |
| http://purl.uniprot.org/citations/16632201 | http://purl.uniprot.org/core/author | "Verghese J."xsd:string |
| http://purl.uniprot.org/citations/16632201 | http://purl.uniprot.org/core/author | "Bressman S."xsd:string |
| http://purl.uniprot.org/citations/16632201 | http://purl.uniprot.org/core/author | "Saunders-Pullman R."xsd:string |
| http://purl.uniprot.org/citations/16632201 | http://purl.uniprot.org/core/author | "Lipton R.B."xsd:string |
| http://purl.uniprot.org/citations/16632201 | http://purl.uniprot.org/core/author | "Senthil G."xsd:string |
| http://purl.uniprot.org/citations/16632201 | http://purl.uniprot.org/core/author | "Costan-Toth C."xsd:string |
| http://purl.uniprot.org/citations/16632201 | http://purl.uniprot.org/core/author | "Derby C."xsd:string |
| http://purl.uniprot.org/citations/16632201 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16632201 | http://purl.uniprot.org/core/name | "Neurosci Lett"xsd:string |
| http://purl.uniprot.org/citations/16632201 | http://purl.uniprot.org/core/pages | "92-96"xsd:string |
| http://purl.uniprot.org/citations/16632201 | http://purl.uniprot.org/core/title | "Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia."xsd:string |
| http://purl.uniprot.org/citations/16632201 | http://purl.uniprot.org/core/volume | "402"xsd:string |
| http://purl.uniprot.org/citations/16632201 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16632201 |
| http://purl.uniprot.org/citations/16632201 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16632201 |
| http://purl.uniprot.org/uniprot/#_A0A218N881-mappedCitation-16632201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16632201 |
| http://purl.uniprot.org/uniprot/#_A2VED2-mappedCitation-16632201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16632201 |
| http://purl.uniprot.org/uniprot/#_Q17RV3-mappedCitation-16632201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16632201 |
| http://purl.uniprot.org/uniprot/#_Q6MZN9-mappedCitation-16632201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16632201 |
| http://purl.uniprot.org/uniprot/#_Q5S007-mappedCitation-16632201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16632201 |
| http://purl.uniprot.org/uniprot/A0A218N881 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16632201 |