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http://purl.uniprot.org/citations/16632353http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16632353http://www.w3.org/2000/01/rdf-schema#comment"We have screened molecules for inhibition of MetAP2 as a novel approach toward antiangiogenesis and anticancer therapy using affinity selection/mass spectrometry (ASMS) employing MetAP2 loaded with Mn(2+) as the active site metal. After a series of anthranilic acid sulfonamides with micromolar affinities was identified, chemistry efforts were initiated. The micromolar hits were quickly improved to potent nanomolar inhibitors by chemical modifications guided by insights from X-ray crystallography."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.org/dc/terms/identifier"doi:10.1016/j.bmcl.2006.03.085"xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Park C."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Zhang Q."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Wang J."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Kawai M."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Vasudevan A."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Hutchins C."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Sanders W.J."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Sheppard G.S."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Henkin J."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Lesniewski R."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Lou P."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Comess K.M."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"BaMaung N.Y."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Bell R.L."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Bouska J."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Erickson S.A."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Tedrow J.S."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Fidanze S.D."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Kalvin D."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/author"Tucker-Garcia L."xsd:string
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16632353http://purl.uniprot.org/core/name"Bioorg Med Chem Lett"xsd:string