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http://purl.uniprot.org/citations/16634885http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16634885http://www.w3.org/2000/01/rdf-schema#comment"

Background

Streptococcal throat infections and HLA Cw6 (Cw*06) have been implicated in the pathogenesis of psoriasis, particularly in the guttate form.

Objectives

To study 105 Irish patients with psoriasis to investigate the relationship between streptococcal infections and Cw*06.

Methods

The patients were divided into two groups: those with guttate psoriasis or guttate flare (guttate group, GG, n=64) and those with chronic plaque psoriasis (chronic plaque group, CPG, n=41).

Results

The incidence of Cw*06 was 86% in the GG and 73% in the CPG, which was not significantly different (P=0.1725) but the incidence in both groups was significantly higher than in an Irish control group (18%) (P<0.0001 vs. GG and P<0.0001 vs. CPG). Evidence for streptococcal infection was higher in the GG (56%) than in the CPG (32%) (P=0.0231). Of those patients with evidence of streptococcal infection, 30 of 36 GG (83%) and nine of 13 CPG (69%) patients possessed the Cw*06 genotype.

Conclusions

Thus, not all patients with streptococcal-related psoriasis carry Cw*06. The role of Cw*06 in psoriasis, if any, has yet to be determined."xsd:string
http://purl.uniprot.org/citations/16634885http://purl.org/dc/terms/identifier"doi:10.1111/j.1365-2133.2005.07101.x"xsd:string
http://purl.uniprot.org/citations/16634885http://purl.uniprot.org/core/author"Ward J."xsd:string
http://purl.uniprot.org/citations/16634885http://purl.uniprot.org/core/author"Rogers S."xsd:string
http://purl.uniprot.org/citations/16634885http://purl.uniprot.org/core/author"Corcoran S."xsd:string
http://purl.uniprot.org/citations/16634885http://purl.uniprot.org/core/author"Fry L."xsd:string
http://purl.uniprot.org/citations/16634885http://purl.uniprot.org/core/author"Powles A.V."xsd:string
http://purl.uniprot.org/citations/16634885http://purl.uniprot.org/core/author"Unsworth D.J."xsd:string
http://purl.uniprot.org/citations/16634885http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16634885http://purl.uniprot.org/core/name"Br J Dermatol"xsd:string
http://purl.uniprot.org/citations/16634885http://purl.uniprot.org/core/pages"850-853"xsd:string
http://purl.uniprot.org/citations/16634885http://purl.uniprot.org/core/title"HLA Cw*06 is not essential for streptococcal-induced psoriasis."xsd:string
http://purl.uniprot.org/citations/16634885http://purl.uniprot.org/core/volume"154"xsd:string
http://purl.uniprot.org/citations/16634885http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16634885
http://purl.uniprot.org/citations/16634885http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16634885
http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-16634885http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16634885
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http://purl.uniprot.org/uniprot/#_A0A0A7C8P1-mappedCitation-16634885http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16634885
http://purl.uniprot.org/uniprot/#_A0A0A7C8P4-mappedCitation-16634885http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16634885
http://purl.uniprot.org/uniprot/#_A0A0A7C8P8-mappedCitation-16634885http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16634885
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http://purl.uniprot.org/uniprot/#_A0A0E3DC64-mappedCitation-16634885http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16634885