| http://purl.uniprot.org/citations/16636677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16636677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16636677 | http://www.w3.org/2000/01/rdf-schema#comment | "Perpetual V(D)J recombinase activity involving multiple DNA double-strand break events in B-cell lineage leukemia and lymphoma cells may introduce secondary genetic aberrations leading towards malignant progression. Here, we investigated defective negative feedback signaling through the (pre-) B-cell receptor as a possible reason for deregulated V(D)J recombinase activity in B-cell malignancy. On studying 28 cases of pre-B-lymphoblastic leukemia and 27 B-cell lymphomas, expression of the (pre-) B-cell receptor-related linker molecule SLP65 (SH2 domain-containing lymphocyte protein of 65 kDa) was found to be defective in seven and five cases, respectively. SLP65 deficiency correlates with RAG1/2 expression and unremitting V(H) gene rearrangement activity. Reconstitution of SLP65 expression in SLP65-deficient leukemia and lymphoma cells results in downregulation of RAG1/2 expression and prevents both de novo V(H)-DJ(H) rearrangements and secondary V(H) replacement. We conclude that iterative V(H) gene rearrangement represents a frequent feature in B-lymphoid malignancy, which can be attributed to SLP65 deficiency in many cases."xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1209520"xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1209520"xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/author | "Siebert R."xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/author | "Siebert R."xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/author | "Feldhahn N."xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/author | "Feldhahn N."xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/author | "Jumaa H."xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/author | "Jumaa H."xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/author | "Liedtke S."xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/author | "Liedtke S."xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/author | "Muschen M."xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/author | "Muschen M."xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/author | "Sprangers M."xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/author | "Sprangers M."xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/pages | "5180-5186"xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/pages | "5180-5186"xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/title | "SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells."xsd:string |
| http://purl.uniprot.org/citations/16636677 | http://purl.uniprot.org/core/title | "SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells."xsd:string |