| http://purl.uniprot.org/citations/16638593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16638593 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveMatrix metalloproteinases (MMPs) play an important role in modeling and remodeling the extracellular matrix in leiomyomas. Hence, we investigated whether associations exist between leiomyomas and promoter polymorphisms in the MMP-1 and MMP-9 genes in a Japanese population.MethodsWe compared the distribution of polymorphisms in the promoter regions of MMP-1 (-1607 1G/2G) and MMP-9 (-1562 C/T) in 267 leiomyoma patients and 184 control patients using polymerase chain reaction-fragment-length polymorphism (PCR-RFLP) analysis.ResultsThe allele frequencies of the MMP-1 -1607 2G and MMP-9 -1562 T polymorphisms were 74.6% and 18.6% in leiomyoma patients, and 71.3% and 18.6% in control patients, respectively. No significant differences in allele frequencies or genotype distributions were found between leiomyoma and control patients. Moreover, no associations were found between MMP-1 and MMP-9 genotypes and leiomyoma size or a family history of the condition.ConclusionThese findings suggest that MMP-1 and MMP-9 promoter polymorphisms are unlikely to be associated with an increased risk of uterine leiomyomas in Japanese women."xsd:string |
| http://purl.uniprot.org/citations/16638593 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jsgi.2006.02.004"xsd:string |
| http://purl.uniprot.org/citations/16638593 | http://purl.uniprot.org/core/author | "Ohara N."xsd:string |
| http://purl.uniprot.org/citations/16638593 | http://purl.uniprot.org/core/author | "Kennedy S."xsd:string |
| http://purl.uniprot.org/citations/16638593 | http://purl.uniprot.org/core/author | "Yoshida S."xsd:string |
| http://purl.uniprot.org/citations/16638593 | http://purl.uniprot.org/core/author | "Maruo T."xsd:string |
| http://purl.uniprot.org/citations/16638593 | http://purl.uniprot.org/core/author | "Deguchi M."xsd:string |
| http://purl.uniprot.org/citations/16638593 | http://purl.uniprot.org/core/author | "Takemura N."xsd:string |
| http://purl.uniprot.org/citations/16638593 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16638593 | http://purl.uniprot.org/core/name | "J Soc Gynecol Investig"xsd:string |
| http://purl.uniprot.org/citations/16638593 | http://purl.uniprot.org/core/pages | "232-236"xsd:string |
| http://purl.uniprot.org/citations/16638593 | http://purl.uniprot.org/core/title | "Matrix metalloproteinase-1 and -9 promoter polymorphisms are not associated with an increased risk of uterine leiomyomas in a Japanese population."xsd:string |
| http://purl.uniprot.org/citations/16638593 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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