| http://purl.uniprot.org/citations/16641491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16641491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16641491 | http://www.w3.org/2000/01/rdf-schema#comment | "Sir3p is a silent-information-regulator (SIR) protein required for the assembly of a transcriptionally "silent" chromatin structure at telomeres and the cryptic HM mating-type loci in Saccharomyces cerevisiae. Sir3p contains a putative "bromo adjacent homology" (BAH) domain at its N terminus that shares strong sequence similarity with the BAH domain of a subunit of the origin recognition complex (ORC), Orc1p. The Orc1p-BAH domain forms a well-defined complex with the ORC interaction region (OIR) of another Sir protein, Sir1p, which targets formation of silent chromatin to the HM-loci. Interestingly, despite sequence similarity of the Sir3p and Orc1p BAH domains and Sir3p's established importance in silencing, Sir3p does not bind the Sir1p-OIR. Here we report the 1.95 A resolution crystal structure of the Sir3p-BAH domain. The structure reveals two key features that can account for Sir3p-BAH domain's inability to interact with Sir1p. First, several Orc1p-BAH domain residues known to directly contact Sir1p are altered in the Sir3p-BAH domain. Second, a critical OIR-binding pocket present on the surface of the Orc1p-BAH domain is "filled" in the Sir3p-BAH domain structure, potentially making it inaccessible to Sir1p. These findings imply that the Sir3p-BAH domain structure has evolved for functions distinct from those of the Orc1p-BAH domain."xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.org/dc/terms/identifier | "doi:10.1110/ps.052061006"xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.org/dc/terms/identifier | "doi:10.1110/ps.052061006"xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/author | "Hou Z."xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/author | "Hou Z."xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/author | "Keck J.L."xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/author | "Keck J.L."xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/author | "Fox C.A."xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/author | "Fox C.A."xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/author | "Danzer J.R."xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/author | "Danzer J.R."xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/name | "Protein Sci."xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/name | "Protein Sci."xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/pages | "1182-1186"xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/pages | "1182-1186"xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/title | "Structure of the Sir3 protein bromo adjacent homology (BAH) domain from S. cerevisiae at 1.95 A resolution."xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/title | "Structure of the Sir3 protein bromo adjacent homology (BAH) domain from S. cerevisiae at 1.95 A resolution."xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/16641491 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16641491 |
| http://purl.uniprot.org/citations/16641491 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16641491 |