| http://purl.uniprot.org/citations/16642042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16642042 | http://www.w3.org/2000/01/rdf-schema#comment | "Synaptotagmin 2 resembles synaptotagmin 1, the Ca2+ sensor for fast neurotransmitter release in forebrain synapses, but little is known about synaptotagmin 2 function. Here, we describe a severely ataxic mouse strain that harbors a single, destabilizing amino-acid substitution (I377N) in synaptotagmin 2. In Calyx of Held synapses, this mutation causes a delay and a decrease in Ca2+-induced but not in hypertonic sucrose-induced release, suggesting that synaptotagmin 2 mediates Ca2+ triggering of evoked release in brainstem synapses. Unexpectedly, we additionally observed in synaptotagmin 2 mutant synapses a dramatic increase in spontaneous release. Synaptotagmin 1-deficient excitatory and inhibitory cortical synapses also displayed a large increase in spontaneous release, demonstrating that this effect was shared among synaptotagmins 1 and 2. Our data suggest that synaptotagmin 1 and 2 perform equivalent functions in the Ca2+ triggering of action potential-induced release and in the restriction of spontaneous release, consistent with a general role of synaptotagmins in controlling 'release slots' for synaptic vesicles at the active zone."xsd:string |
| http://purl.uniprot.org/citations/16642042 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601103"xsd:string |
| http://purl.uniprot.org/citations/16642042 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/16642042 | http://purl.uniprot.org/core/author | "Sudhof T.C."xsd:string |
| http://purl.uniprot.org/citations/16642042 | http://purl.uniprot.org/core/author | "Rizo J."xsd:string |
| http://purl.uniprot.org/citations/16642042 | http://purl.uniprot.org/core/author | "Pang Z.P."xsd:string |
| http://purl.uniprot.org/citations/16642042 | http://purl.uniprot.org/core/author | "Maximov A."xsd:string |
| http://purl.uniprot.org/citations/16642042 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16642042 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/16642042 | http://purl.uniprot.org/core/pages | "2039-2050"xsd:string |
| http://purl.uniprot.org/citations/16642042 | http://purl.uniprot.org/core/title | "Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release."xsd:string |
| http://purl.uniprot.org/citations/16642042 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16642042 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16642042 |
| http://purl.uniprot.org/citations/16642042 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16642042 |
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| http://purl.uniprot.org/uniprot/#_P63044-mappedCitation-16642042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16642042 |
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| http://purl.uniprot.org/uniprot/#_P60879-mappedCitation-16642042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16642042 |
| http://purl.uniprot.org/uniprot/#_Q497P1-mappedCitation-16642042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16642042 |
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