| http://purl.uniprot.org/citations/16645094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16645094 | http://www.w3.org/2000/01/rdf-schema#comment | "Accumulation of misfolded protein in the endoplasmic reticulum (ER) triggers an adaptive stress response-termed the unfolded protein response (UPR)-mediated by the ER transmembrane protein kinase and endoribonuclease inositol-requiring enzyme-1alpha (IRE1alpha). We investigated UPR signaling events in mice in the absence of the proapoptotic BCL-2 family members BAX and BAK [double knockout (DKO)]. DKO mice responded abnormally to tunicamycin-induced ER stress in the liver, with extensive tissue damage and decreased expression of the IRE1 substrate X-box-binding protein 1 and its target genes. ER-stressed DKO cells showed deficient IRE1alpha signaling. BAX and BAK formed a protein complex with the cytosolic domain of IRE1alpha that was essential for IRE1alpha activation. Thus, BAX and BAK function at the ER membrane to activate IRE1alpha signaling and to provide a physical link between members of the core apoptotic pathway and the UPR."xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1123480"xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/author | "Bernasconi P."xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/author | "Lee A.H."xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/author | "Brandt G.S."xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/author | "Bassik M.C."xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/author | "Glimcher L.H."xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/author | "Schinzel A."xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/author | "Hetz C."xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/author | "Korsmeyer S.J."xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/author | "Fisher J."xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/author | "Antonsson B."xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/author | "Iwakoshi N.N."xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/pages | "572-576"xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/title | "Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha."xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://purl.uniprot.org/core/volume | "312"xsd:string |
| http://purl.uniprot.org/citations/16645094 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16645094 |
| http://purl.uniprot.org/citations/16645094 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16645094 |
| http://purl.uniprot.org/uniprot/Q16611#attribution-63C891CE6A3F07432A662B1F2480F11E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16645094 |
| http://purl.uniprot.org/uniprot/Q07812#attribution-63C891CE6A3F07432A662B1F2480F11E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16645094 |
| http://purl.uniprot.org/uniprot/O75460#attribution-63C891CE6A3F07432A662B1F2480F11E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16645094 |
| http://purl.uniprot.org/uniprot/P17861#attribution-63C891CE6A3F07432A662B1F2480F11E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16645094 |