| http://purl.uniprot.org/citations/16645141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16645141 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated whether the mobilization of endothelial progenitor cells (EPCs) by exogenous erythropoietin (Epo) promotes the repair of injured endothelium. Recombinant human Epo was injected (1000 IU/kg for the initial 3 days) after wire injury of the femoral artery of mice. Neointimal formation was inhibited by Epo to 48% of the control (P<0.05) in an NO-dependent manner. Epo induced a 1.4-fold increase in reendothelialized area of day 14 denuded vessels, 55% of which was derived from bone marrow (BM) cells. Epo increased the circulating Sca-1(+)/Flk-1(+) EPCs (2.0-fold, P<0.05) with endothelial properties NO dependently. BM replacement by GFP- or beta-galactosidase-overexpressing cells showed that Epo stimulated both differentiation of BM-derived EPCs and proliferation of resident ECs. BM-derived ECs increased 2.2-to 2.7-fold (P<0.05) in the Epo-induced neoendothelium, where the expression of Epo receptor was upregulated. Epo induced Akt/eNOS phosphorylation and NO synthesis on EPCs and exerted an antiapoptotic action on wire-injured arteries. In conclusion, Epo treatment inhibits the neointimal hyperplasia after arterial injury in an NO-dependent manner by acting on the injured vessels and mobilizing EPCs to the neo-endothelium."xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.res.0000224117.59417.f3"xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/author | "Matsunaga S."xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/author | "Matsubara H."xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/author | "Takahashi T."xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/author | "Yamada H."xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/author | "Nomura T."xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/author | "Matsuno K."xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/author | "Matsui A."xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/author | "Tatsumi T."xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/author | "Tateishi K."xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/author | "Okigaki M."xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/author | "Urao N."xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/author | "Aadachi Y."xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/pages | "1405-1413"xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/title | "Erythropoietin-mobilized endothelial progenitors enhance reendothelialization via Akt-endothelial nitric oxide synthase activation and prevent neointimal hyperplasia."xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://purl.uniprot.org/core/volume | "98"xsd:string |
| http://purl.uniprot.org/citations/16645141 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16645141 |
| http://purl.uniprot.org/citations/16645141 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16645141 |
| http://purl.uniprot.org/uniprot/#_A4FUQ9-mappedCitation-16645141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16645141 |
| http://purl.uniprot.org/uniprot/#_B7ZKK5-mappedCitation-16645141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16645141 |
| http://purl.uniprot.org/uniprot/#_G9JKG7-mappedCitation-16645141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16645141 |