| http://purl.uniprot.org/citations/16648845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16648845 | http://www.w3.org/2000/01/rdf-schema#comment | "The temporal control of mitotic protein degradation remains incompletely understood. In particular, it is unclear why the mitotic checkpoint prevents the anaphase-promoting complex/cyclosome (APC/C)-mediated degradation of cyclin B and securin in early mitosis, but not cyclin A. Here, we show that another APC/C substrate, NIMA-related kinase 2A (Nek2A), is also destroyed in pro-metaphase in a checkpoint-independent manner and that this depends on an exposed carboxy-terminal methionine-arginine (MR) dipeptide tail. Truncation of the Nek2A C terminus delays its degradation until late mitosis, whereas Nek2A C-terminal peptides interfere with APC/C activity in an MR-dependent manner. Most importantly, we show that Nek2A binds directly to the APC/C, also in an MR-dependent manner, even in the absence of the adaptor protein Cdc20. As similar C-terminal dipeptide tails promote direct association of Cdc20, Cdh1 and Apc10-Doc1 with core APC/C subunits, we propose that this sequence also allows a substrate, Nek2A, to directly bind the APC/C. Thus, although Cdc20 is required for the degradation of Nek2A, it is not required for its recruitment and this renders its degradation insensitive to the mitotic checkpoint."xsd:string |
| http://purl.uniprot.org/citations/16648845 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1410"xsd:string |
| http://purl.uniprot.org/citations/16648845 | http://purl.uniprot.org/core/author | "Yamano H."xsd:string |
| http://purl.uniprot.org/citations/16648845 | http://purl.uniprot.org/core/author | "Mao G."xsd:string |
| http://purl.uniprot.org/citations/16648845 | http://purl.uniprot.org/core/author | "Kimata Y."xsd:string |
| http://purl.uniprot.org/citations/16648845 | http://purl.uniprot.org/core/author | "Hayes M.J."xsd:string |
| http://purl.uniprot.org/citations/16648845 | http://purl.uniprot.org/core/author | "Lindon C."xsd:string |
| http://purl.uniprot.org/citations/16648845 | http://purl.uniprot.org/core/author | "Fry A.M."xsd:string |
| http://purl.uniprot.org/citations/16648845 | http://purl.uniprot.org/core/author | "Wattam S.L."xsd:string |
| http://purl.uniprot.org/citations/16648845 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16648845 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16648845 | http://purl.uniprot.org/core/pages | "607-614"xsd:string |
| http://purl.uniprot.org/citations/16648845 | http://purl.uniprot.org/core/title | "Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C."xsd:string |
| http://purl.uniprot.org/citations/16648845 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/16648845 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16648845 |
| http://purl.uniprot.org/citations/16648845 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16648845 |
| http://purl.uniprot.org/uniprot/#_P0CG47-mappedCitation-16648845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16648845 |
| http://purl.uniprot.org/uniprot/#_P0CG48-mappedCitation-16648845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16648845 |
| http://purl.uniprot.org/uniprot/#_P51955-mappedCitation-16648845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16648845 |
| http://purl.uniprot.org/uniprot/#_P51965-mappedCitation-16648845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16648845 |
| http://purl.uniprot.org/uniprot/#_Q12834-mappedCitation-16648845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16648845 |
| http://purl.uniprot.org/uniprot/#_Q13042-mappedCitation-16648845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16648845 |
| http://purl.uniprot.org/uniprot/#_Q13257-mappedCitation-16648845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16648845 |
| http://purl.uniprot.org/uniprot/#_P51668-mappedCitation-16648845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16648845 |