| http://purl.uniprot.org/citations/16651634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16651634 | http://www.w3.org/2000/01/rdf-schema#comment | "Benign peripheral nerve tumors called neurofibromas are a major source of morbidity for patients with neurofibromatosis type 1. Some neurofibroma Schwann cells aberrantly express the epidermal growth factor receptor (EGFR). In a mouse model in which the CNPase promoter drives expression of human EGFR in Schwann cells, nerves develop hypertrophy, mast cell accumulation, collagen deposition, disruption of axon-glial interactions, characteristics of neurofibroma and are hypoalgesic. Administration of the EGFR antagonist cetuximab (IMC-C225) for 2 weeks beginning at birth in CNPase-hEGFR mice normalized all pathologies at 3 months of age as evaluated by hotplate testing or histology and by electron microscopy. Mast cell chemoattractants brain-derived neurotrophic factor, monocyte chemoattractant protein-1, and transforming growth factor-beta1, which may account for mast cell accumulation and fibrosis, were reduced by cetuximab. Later treatment was much less effective. A birth to 2-week pulse of cetuximab blocked hEGFR phosphorylation and Schwann cell prolifera-tion in perinatal mutant nerve, so CNPase-hEGFR Schwann cell numbers correlate with the cetuximab effect. A >250-fold enlarged population of EGFR(+)/p75(+) cells was detected in newborn Nf1(+/-) mouse nerves. These results suggest the existence of an EGFR(+) cell enriched in the perinatal period capable of driving complex changes characteristic of neurofibroma formation."xsd:string |
| http://purl.uniprot.org/citations/16651634 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2006.050859"xsd:string |
| http://purl.uniprot.org/citations/16651634 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/16651634 | http://purl.uniprot.org/core/author | "Monk K.R."xsd:string |
| http://purl.uniprot.org/citations/16651634 | http://purl.uniprot.org/core/author | "Tedesco S."xsd:string |
| http://purl.uniprot.org/citations/16651634 | http://purl.uniprot.org/core/author | "Williams J.P."xsd:string |
| http://purl.uniprot.org/citations/16651634 | http://purl.uniprot.org/core/author | "Fitzgerald M.E."xsd:string |
| http://purl.uniprot.org/citations/16651634 | http://purl.uniprot.org/core/author | "Ratner N."xsd:string |
| http://purl.uniprot.org/citations/16651634 | http://purl.uniprot.org/core/author | "Crimmins J.T."xsd:string |
| http://purl.uniprot.org/citations/16651634 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16651634 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/16651634 | http://purl.uniprot.org/core/pages | "1686-1696"xsd:string |
| http://purl.uniprot.org/citations/16651634 | http://purl.uniprot.org/core/title | "Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma."xsd:string |
| http://purl.uniprot.org/citations/16651634 | http://purl.uniprot.org/core/volume | "168"xsd:string |
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