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| http://purl.uniprot.org/citations/16670297 | http://www.w3.org/2000/01/rdf-schema#comment | "Human CD2 regulates T cell activation and adhesion via mechanisms yet to be fully understood. This study focuses on CD2BP1, a CD2 cytoplasmic tail-binding protein preferentially expressed in hematopoetic cells. Structural and functional analyses suggest that CD2BP1 acts as a scaffold protein, participating in regulation of the actin cytoskeleton. In this study, using a murine Ag-specific primary T cell transduction system to assess CD69, IL-2, and IFN-gamma expression, we provide evidence that CD2BP1 directly and negatively impacts T cell activation via isolated CD2 triggering or TCR stimulation dependent on coordinate CD2 engagement. Disruption of protein tyrosine phosphatase-PEST and/or CD2BP1 association with the CD2 signalsome rescues T cells from the inhibitory effect of CD2 crosslinking. The overexpression of CD2BP1 selectively attenuates phospholipase Cgamma1, ERK1/2, and p38 phosphorylation without abrogating CD2-independent TCR stimulation. This study provides new insight on the regulation of T cell activation and may have implications for autoimmune processes known to be associated with CD2BP1 mutations."xsd:string |
| http://purl.uniprot.org/citations/16670297 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.176.10.5898"xsd:string |
| http://purl.uniprot.org/citations/16670297 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/16670297 | http://purl.uniprot.org/core/author | "Reinherz E.L."xsd:string |
| http://purl.uniprot.org/citations/16670297 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16670297 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16670297 | http://purl.uniprot.org/core/pages | "5898-5907"xsd:string |
| http://purl.uniprot.org/citations/16670297 | http://purl.uniprot.org/core/title | "CD2BP1 modulates CD2-dependent T cell activation via linkage to protein tyrosine phosphatase (PTP)-PEST."xsd:string |
| http://purl.uniprot.org/citations/16670297 | http://purl.uniprot.org/core/volume | "176"xsd:string |
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