| http://purl.uniprot.org/citations/16672365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16672365 | http://www.w3.org/2000/01/rdf-schema#comment | "The FHIT gene has many hallmarks of a tumor-suppressor gene and is involved in a large variety of cancers. We treated A/J mice and (C57BL/6J x 129/SvJ)F1 (B6/129 F1) mice, either wild-type or FHIT+/-, with multiple doses of benzo[a]pyrene (B[a]P) by gavage. B[a]P caused a time-related increase of micronuclei in peripheral blood erythrocytes. Both A/J and B6/129 F1 mice, irrespective of their FHIT status, were sensitive to induction of forestomach tumors, whereas B[a]P induced glandular stomach hyperplasia and a high multiplicity of lung tumors in A/J mice only. Preneoplastic lesions of the uterus were more frequent in FHIT+/-mice. B6/129 F1 mice underwent spontaneous alopecia areata and hair bulb cell apoptosis, which were greatly accelerated either by FHIT heterozygosity or by B[a]P treatment, thus suggesting that FHIT plays a role in the pathogenesis of alopecia areata. The oral administration of either budesonide or N-acetyl-L-cysteine (NAC) inhibited the occurrence of this inflammatory skin disease. In addition, these agents prevented B[a]P-induced glandular stomach hyperplasia and decreased the size of both forestomach tumors and lung tumors in A/J mice. Budesonide also attenuated lung tumor multiplicity. In B6/129 F1 mice, NAC significantly decreased the proliferating cell nuclear antigen in lung tumors. Both budesonide and NAC inhibited B[a]P-induced forestomach tumors and preneoplastic lesions of the respiratory tract in B6/129 F1 mice. In conclusion, heterozygosity for FHIT affects susceptibility of mice to spontaneous alopecia areata and B[a]P-induced preneoplastic lesions of the uterus and does not alter responsiveness to budesonide and NAC."xsd:string |
| http://purl.uniprot.org/citations/16672365 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0601412103"xsd:string |
| http://purl.uniprot.org/citations/16672365 | http://purl.uniprot.org/core/author | "Croce C.M."xsd:string |
| http://purl.uniprot.org/citations/16672365 | http://purl.uniprot.org/core/author | "Lubet R.A."xsd:string |
| http://purl.uniprot.org/citations/16672365 | http://purl.uniprot.org/core/author | "Zanesi N."xsd:string |
| http://purl.uniprot.org/citations/16672365 | http://purl.uniprot.org/core/author | "Di Marco B."xsd:string |
| http://purl.uniprot.org/citations/16672365 | http://purl.uniprot.org/core/author | "D'Agostini F."xsd:string |
| http://purl.uniprot.org/citations/16672365 | http://purl.uniprot.org/core/author | "De Flora S."xsd:string |
| http://purl.uniprot.org/citations/16672365 | http://purl.uniprot.org/core/author | "Izzotti A."xsd:string |
| http://purl.uniprot.org/citations/16672365 | http://purl.uniprot.org/core/author | "Balansky R."xsd:string |
| http://purl.uniprot.org/citations/16672365 | http://purl.uniprot.org/core/author | "Ganchev G."xsd:string |
| http://purl.uniprot.org/citations/16672365 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16672365 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/16672365 | http://purl.uniprot.org/core/pages | "7823-7828"xsd:string |
| http://purl.uniprot.org/citations/16672365 | http://purl.uniprot.org/core/title | "Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: chemoprevention by budesonide and N-acetylcysteine."xsd:string |
| http://purl.uniprot.org/citations/16672365 | http://purl.uniprot.org/core/volume | "103"xsd:string |
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