| http://purl.uniprot.org/citations/16676006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16676006 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of c-Jun, a component of the AP-1 family of transcription factors, leads to either promotion or prevention of apoptosis. However, the molecular determinants of c-Jun-mediated cell survival are still unclear. We show here that inducible expression of c-Jun promotes cellular survival by negatively regulating the expression of the tumor-suppressor PTEN, resulting in the concomitant activation of the Akt survival pathway. Consistently, c-jun-/-fibroblasts, which are sensitive to nutrient deprivation, and human cell lines in which c-Jun expression is silenced, express elevated levels of PTEN. siRNA-mediated silencing of PTEN resulted in the reduction of cell-death owing to c-Jun deficiency. c-Jun was found to suppress PTEN expression by binding to a variant AP-1 site found in the 5' upstream sequences of PTEN promoter. Finally, an inverse correlation between c-Jun and PTEN levels was apparent in a panel of human tumor cell lines, independent of their p53 status. Together, the data demonstrate that c-Jun contributes to the promotion of cellular survival by regulating the expression of PTEN."xsd:string |
| http://purl.uniprot.org/citations/16676006 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4401946"xsd:string |
| http://purl.uniprot.org/citations/16676006 | http://purl.uniprot.org/core/author | "Zhang J.T."xsd:string |
| http://purl.uniprot.org/citations/16676006 | http://purl.uniprot.org/core/author | "Lee M.K."xsd:string |
| http://purl.uniprot.org/citations/16676006 | http://purl.uniprot.org/core/author | "Reddy S.A."xsd:string |
| http://purl.uniprot.org/citations/16676006 | http://purl.uniprot.org/core/author | "Sabapathy K."xsd:string |
| http://purl.uniprot.org/citations/16676006 | http://purl.uniprot.org/core/author | "de Belle I."xsd:string |
| http://purl.uniprot.org/citations/16676006 | http://purl.uniprot.org/core/author | "Poh M.K."xsd:string |
| http://purl.uniprot.org/citations/16676006 | http://purl.uniprot.org/core/author | "Vikhanskaya F."xsd:string |
| http://purl.uniprot.org/citations/16676006 | http://purl.uniprot.org/core/author | "Hettinger K."xsd:string |
| http://purl.uniprot.org/citations/16676006 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/16676006 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/16676006 | http://purl.uniprot.org/core/pages | "218-229"xsd:string |
| http://purl.uniprot.org/citations/16676006 | http://purl.uniprot.org/core/title | "c-Jun promotes cellular survival by suppression of PTEN."xsd:string |
| http://purl.uniprot.org/citations/16676006 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/16676006 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16676006 |
| http://purl.uniprot.org/citations/16676006 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16676006 |
| http://purl.uniprot.org/uniprot/#_A0A024QYR6-mappedCitation-16676006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16676006 |
| http://purl.uniprot.org/uniprot/#_P15336-mappedCitation-16676006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16676006 |
| http://purl.uniprot.org/uniprot/#_P54259-mappedCitation-16676006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16676006 |
| http://purl.uniprot.org/uniprot/#_Q15022-mappedCitation-16676006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16676006 |
| http://purl.uniprot.org/uniprot/#_A0A142FGX1-mappedCitation-16676006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16676006 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TPK6-mappedCitation-16676006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16676006 |
| http://purl.uniprot.org/uniprot/#_A0A1V0DNR7-mappedCitation-16676006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16676006 |