| http://purl.uniprot.org/citations/16678093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16678093 | http://www.w3.org/2000/01/rdf-schema#comment | "Postnatal cardiac myocytes respond to diverse signals by hypertrophic growth and activation of a fetal gene program. In an effort to discover regulators of cardiac hypertrophy, we performed a eukaryotic expression screen for activators of the atrial natriuretic factor (ANF) gene, a cardiac-specific marker of hypertrophic signaling. We discovered that a family of transcriptional coactivators, called CAMTAs, promotes cardiomyocyte hypertrophy and activates the ANF gene, at least in part, by associating with the cardiac homeodomain protein Nkx2-5. The transcriptional activity of CAMTAs is governed by association with class II histone deacetylases (HDACs), which negatively regulate cardiac growth. Mice homozygous for a mutation in a CAMTA gene are defective in cardiac growth in response to pressure overload and neurohumoral signaling, whereas mice lacking HDAC5, a class II HDAC, are sensitized to the prohypertrophic actions of CAMTA. These findings reveal a transcriptional regulatory mechanism that modulates cardiac growth and gene expression by linking hypertrophic signals to the cardiac genome."xsd:string |
| http://purl.uniprot.org/citations/16678093 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.02.048"xsd:string |
| http://purl.uniprot.org/citations/16678093 | http://purl.uniprot.org/core/author | "Qi X."xsd:string |
| http://purl.uniprot.org/citations/16678093 | http://purl.uniprot.org/core/author | "Song K."xsd:string |
| http://purl.uniprot.org/citations/16678093 | http://purl.uniprot.org/core/author | "Hill J.A."xsd:string |
| http://purl.uniprot.org/citations/16678093 | http://purl.uniprot.org/core/author | "Gerard R.D."xsd:string |
| http://purl.uniprot.org/citations/16678093 | http://purl.uniprot.org/core/author | "Bassel-Duby R."xsd:string |
| http://purl.uniprot.org/citations/16678093 | http://purl.uniprot.org/core/author | "Olson E.N."xsd:string |
| http://purl.uniprot.org/citations/16678093 | http://purl.uniprot.org/core/author | "Richardson J.A."xsd:string |
| http://purl.uniprot.org/citations/16678093 | http://purl.uniprot.org/core/author | "Backs J."xsd:string |
| http://purl.uniprot.org/citations/16678093 | http://purl.uniprot.org/core/author | "McAnally J."xsd:string |
| http://purl.uniprot.org/citations/16678093 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16678093 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16678093 | http://purl.uniprot.org/core/pages | "453-466"xsd:string |
| http://purl.uniprot.org/citations/16678093 | http://purl.uniprot.org/core/title | "The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases."xsd:string |
| http://purl.uniprot.org/citations/16678093 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/16678093 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16678093 |
| http://purl.uniprot.org/citations/16678093 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16678093 |
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| http://purl.uniprot.org/uniprot/#_A0A494B983-mappedCitation-16678093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16678093 |