| http://purl.uniprot.org/citations/16682406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16682406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16682406 | http://www.w3.org/2000/01/rdf-schema#comment | "The mouse genome sequence has been examined to identify the complete set of proteins related to the human glycanbinding receptor, DC-SIGN. In addition to five SIGNR proteins previously described, a pseudogene, encoding a hypothetical SIGNR6, and a further two expressed proteins, SIGNR7 and SIGNR8, have been identified. The ligand-binding properties of these novel proteins and of the previously described mouse SIGNs have been systematically investigated in order to define the mouse proteins that most resemble human DC-SIGN and DC-SIGNR. Results from screening of a glycan array demonstrate that only mouse SIGNR3 shares with human DC-SIGN the ability to bind both high mannose and fucose-terminated glycans in this format and to mediate endocytosis. The finding that neither SIGNR1 nor SIGNR5 binds with high affinity to specific ligands in a large panel of mammalian glycans is consistent with the suggestion that these receptors bind surface polysaccharides on bacterial and fungal pathogens in a manner analogous to serum mannose-binding protein. The data also reveal that two of the mouse SIGNs have unusual binding specificities that have not been previously described for members of the C-type lectin family; the newly identified SIGNR7 binds preferentially to the 6-sulfo-sialyl Lewis(x) oligosaccharide, whereas SIGNR2 binds almost exclusively to glycans that bear terminal GlcNAc residues. The results presented demonstrate that the mouse homologs of DC-SIGN have a diverse set of ligand-binding and intracellular trafficking properties, some of which are distinct from the properties of any of the human receptors."xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.M601925200"xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m601925200"xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/author | "Taylor M.E."xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/author | "Taylor M.E."xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/author | "Drickamer K."xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/author | "Drickamer K."xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/author | "Powlesland A.S."xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/author | "Powlesland A.S."xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/author | "Ward E.M."xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/author | "Ward E.M."xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/author | "Sadhu S.K."xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/author | "Sadhu S.K."xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/pages | "20440-20449"xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/pages | "20440-20449"xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/title | "Widely divergent biochemical properties of the complete set of mouse DC-SIGN-related proteins."xsd:string |
| http://purl.uniprot.org/citations/16682406 | http://purl.uniprot.org/core/title | "Widely divergent biochemical properties of the complete set of mouse DC-SIGN-related proteins."xsd:string |