| http://purl.uniprot.org/citations/16690024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16690024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16690024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/16690024 | http://www.w3.org/2000/01/rdf-schema#comment | "ADP-ribosyl cyclases (ADPRCs) are present from lower Metazoa to mammals and synthesize the Ca2+-active (di)nucleotides cyclic ADP-ribose (cADPR), NAADP+, and ADP-ribose (ADPR), involved in the regulation of important cellular functions. NAADP+ can be synthesized by ADPRCs from NADP+ through a base-exchange reaction, which substitutes nicotinamide for nicotinic acid (NA). Here we demonstrate that ADPRCs from both lower and higher Metazoa (including human CD38) can also synthesize NAADP+ starting from 2'-phospho-cyclic ADP-ribose (cADPRP) and NA. Comparison, on the two substrates cADPRP and NADP+, of the relative rates of the reactions introducing NA and hydrolyzing/cyclizing the substrate, respectively, indicates that with all ADPRCs tested cADPRP is preferentially transformed into NAADP+, while NADP+ is preferentially cyclized or hydrolyzed to cADPRP/2'-phospho-ADP-ribose. cADPRP was detectable in retinoic acid-differentiated, CD38+ HL-60 cells, but not in undifferentiated, CD38-cells. These results suggest that cADPRP may be a NAADP+ precursor in ADPRC+ cells."xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.04.096"xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.04.096"xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/author | "Bruzzone S."xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/author | "Bruzzone S."xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/author | "De Flora A."xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/author | "De Flora A."xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/author | "Melone L."xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/author | "Melone L."xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/author | "Moreschi I."xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/author | "Moreschi I."xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/author | "Zocchi E."xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/author | "Zocchi E."xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/pages | "573-580"xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/pages | "573-580"xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/title | "NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases."xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/title | "NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases."xsd:string |
| http://purl.uniprot.org/citations/16690024 | http://purl.uniprot.org/core/volume | "345"xsd:string |