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http://purl.uniprot.org/citations/16690874http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16690874http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Identify gene variants associated with early-onset myocardial infarction (MI).

Methods and results

We tested 11 647 single-nucleotide polymorphisms (SNPs) for association with early-onset MI in a case-control study (study 1 200 cases, 262 controls). To reduce the number of false positives among the 666 SNPs that were nominally associated with early-onset MI (P<0.05) in study 1, we tested these SNPs in study 2 (434 cases, 504 controls). We found that 8 of the 666 SNPs were associated with early-onset MI in study 2 (P<0.05) and had the same risk alleles as in study 1. These 8 SNPs were then tested for association with early-onset MI in study 3 (187 cases, 434 controls). We found that a VAMP8 variant (P = 0.025; odds ratio [OR], 1.75; CI, 1.17 to 2.62) and an HNRPUL1 variant (P = 0.0043; OR, 1.92; CI, 1.28 to 2.86) were associated with early-onset MI (nominal P<0.05; false discovery rate <10%) and had the same risk alleles in all 3 studies.

Conclusions

Variants in 2 genes were associated with early-onset MI: VAMP8, which is involved in platelet degranulation, and HNRPUL1, which encodes a ribonuclear protein. The identification of these variants could improve understanding of disease mechanisms and suggest novel drug targets."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.org/dc/terms/identifier"doi:10.1161/01.atv.0000226543.77214.e4"xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/author"Catanese J.J."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/author"Shiffman D."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/author"Topol E.J."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/author"Kane J.P."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/author"Malloy M.J."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/author"Pullinger C.R."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/author"Luke M.M."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/author"Devlin J.J."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/author"Bare L.A."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/author"Ellis S.G."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/author"Young B.A."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/author"Rowland C.M."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/author"Bolonick J.I."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/author"Louie J.Z."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/author"Stiggins C.F."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/name"Arterioscler Thromb Vasc Biol"xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/pages"1613-1618"xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/title"Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction."xsd:string
http://purl.uniprot.org/citations/16690874http://purl.uniprot.org/core/volume"26"xsd:string
http://purl.uniprot.org/citations/16690874http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16690874
http://purl.uniprot.org/citations/16690874http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16690874
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