| http://purl.uniprot.org/citations/16691186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16691186 | http://www.w3.org/2000/01/rdf-schema#comment | "Type II diabetes is caused by a failure of the pancreatic beta-cells to compensate for insulin resistance leading to hyperglycaemia. There is evidence for an essential role of an increased beta-cell apoptosis in type II diabetes. High glucose concentrations induce IL-1beta production in human beta-cells, Fas expression and concomitant apoptosis owing to a constitutive expression of FasL. FASL and FAS map to loci linked to type II diabetes and estimates of insulin resistance, respectively. We have tested two functional promoter polymorphisms, FAS-670 G>A and FASL-844C>T as well as a microsatellite in the 3' UTR of FASL for association to type II diabetes in 549 type II diabetic patients and 525 normal-glucose-tolerant (NGT) control subjects. Furthermore, we have tested these polymorphisms for association to estimates of beta-cell function and insulin resistance in NGT subjects. We found significant association to type II diabetes for the allele distribution of the FASL microsatellite (P-value 0.02, Bonferroni corrected). The FAS-670G>A was associated with homeostasis model assessment insulin resistance index and body mass index (P-values 0.02 and 0.02). We conclude that polymorphisms of FASL and FAS associate with type II diabetes and estimates of insulin resistance in Danish white subjects."xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.gene.6364300"xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://purl.uniprot.org/core/author | "Hansen T."xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://purl.uniprot.org/core/author | "Paulsen S."xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://purl.uniprot.org/core/author | "Pedersen O."xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://purl.uniprot.org/core/author | "Borch-Johnsen K."xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://purl.uniprot.org/core/author | "Drivsholm T."xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://purl.uniprot.org/core/author | "Hamid Y.H."xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://purl.uniprot.org/core/author | "Andersen K.M."xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://purl.uniprot.org/core/author | "Pociot F."xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://purl.uniprot.org/core/author | "Mandrup-Poulsen T."xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://purl.uniprot.org/core/author | "Nolsoe R.L."xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16691186 | http://purl.uniprot.org/core/name | "Genes Immun"xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://purl.uniprot.org/core/pages | "316-321"xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://purl.uniprot.org/core/title | "Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance."xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/16691186 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16691186 |
| http://purl.uniprot.org/citations/16691186 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16691186 |
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| http://purl.uniprot.org/uniprot/#_A0A1C6ZWA8-mappedCitation-16691186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16691186 |
| http://purl.uniprot.org/uniprot/#_A0A0H3VB22-mappedCitation-16691186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16691186 |
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| http://purl.uniprot.org/uniprot/#_E6Y7C3-mappedCitation-16691186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16691186 |