| http://purl.uniprot.org/citations/16697960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16697960 | http://www.w3.org/2000/01/rdf-schema#comment | "Our understanding of Ewing's sarcoma development mediated by the EWS/FLI fusion protein has been limited by a lack of knowledge regarding the tumor cell of origin. To circumvent this, we analyzed the function of EWS/FLI in Ewing's sarcoma itself. By combining retroviral-mediated RNA interference with reexpression studies, we show that ongoing EWS/FLI expression is required for the tumorigenic phenotype of Ewing's sarcoma. We used this system to define the full complement of EWS/FLI-regulated genes in Ewing's sarcoma. Functional analysis revealed that NKX2.2 is an EWS/FLI-regulated gene that is necessary for oncogenic transformation in this tumor. Thus, we developed a highly validated transcriptional profile for the EWS/FLI fusion protein and identified a critical target gene in Ewing's sarcoma development."xsd:string |
| http://purl.uniprot.org/citations/16697960 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2006.04.004"xsd:string |
| http://purl.uniprot.org/citations/16697960 | http://purl.uniprot.org/core/author | "Smith R."xsd:string |
| http://purl.uniprot.org/citations/16697960 | http://purl.uniprot.org/core/author | "Owen L.A."xsd:string |
| http://purl.uniprot.org/citations/16697960 | http://purl.uniprot.org/core/author | "Golub T.R."xsd:string |
| http://purl.uniprot.org/citations/16697960 | http://purl.uniprot.org/core/author | "Whangbo J.S."xsd:string |
| http://purl.uniprot.org/citations/16697960 | http://purl.uniprot.org/core/author | "Wong J.S."xsd:string |
| http://purl.uniprot.org/citations/16697960 | http://purl.uniprot.org/core/author | "Lessnick S.L."xsd:string |
| http://purl.uniprot.org/citations/16697960 | http://purl.uniprot.org/core/author | "Trem D.J."xsd:string |
| http://purl.uniprot.org/citations/16697960 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16697960 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/16697960 | http://purl.uniprot.org/core/pages | "405-416"xsd:string |
| http://purl.uniprot.org/citations/16697960 | http://purl.uniprot.org/core/title | "Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma."xsd:string |
| http://purl.uniprot.org/citations/16697960 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/16697960 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16697960 |
| http://purl.uniprot.org/citations/16697960 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16697960 |
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| http://purl.uniprot.org/uniprot/#_Q9HBZ5-mappedCitation-16697960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16697960 |
| http://purl.uniprot.org/uniprot/Q9HBZ5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16697960 |
| http://purl.uniprot.org/uniprot/O95096 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16697960 |