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http://purl.uniprot.org/citations/16698994http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16698994http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16698994http://www.w3.org/2000/01/rdf-schema#comment"The packaging of viral genomic RNA into nucleocapsids and subsequently into virions is not completely understood. Phosphoprotein (P) and nucleoprotein (NP) interactions link NP-RNA complexes with P-L (polymerase) complexes to form viral nucleocapsids. The nucleocapsid then interacts with the viral matrix protein, leading to specific packaging of the nucleocapsid into the virion. A mammalian two-hybrid assay and confocal microscopy were used to demonstrate that Ebola virus VP35 and VP40 interact and colocalize in transfected cells. VP35 was packaged into budding virus-like particles (VLPs) as observed by protease protection assays. Moreover, VP40 and VP35 were sufficient for packaging an Ebola virus minigenome RNA into VLPs. Results from immunoprecipitation-reverse transcriptase PCR experiments suggest that VP35 confers specificity of the nucleocapsid for viral genomic RNA by direct VP35-RNA interactions."xsd:string
http://purl.uniprot.org/citations/16698994http://purl.org/dc/terms/identifier"doi:10.1128/jvi.01857-05"xsd:string
http://purl.uniprot.org/citations/16698994http://purl.org/dc/terms/identifier"doi:10.1128/jvi.01857-05"xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/author"Harty R.N."xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/author"Harty R.N."xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/author"McCarthy S.E."xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/author"McCarthy S.E."xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/author"Johnson R.F."xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/author"Johnson R.F."xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/author"Godlewski P.J."xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/author"Godlewski P.J."xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/name"J. Virol."xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/name"J. Virol."xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/pages"5135-5144"xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/pages"5135-5144"xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/title"Ebola virus VP35-VP40 interaction is sufficient for packaging 3E-5E minigenome RNA into virus-like particles."xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/title"Ebola virus VP35-VP40 interaction is sufficient for packaging 3E-5E minigenome RNA into virus-like particles."xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/volume"80"xsd:string
http://purl.uniprot.org/citations/16698994http://purl.uniprot.org/core/volume"80"xsd:string
http://purl.uniprot.org/citations/16698994http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16698994
http://purl.uniprot.org/citations/16698994http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16698994