| http://purl.uniprot.org/citations/16701209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16701209 | http://www.w3.org/2000/01/rdf-schema#comment | "GABAB receptors are the G protein-coupled receptors for the main inhibitory neurotransmitter in the brain, gamma-aminobutyric acid (GABA). Molecular diversity in the GABAB system arises from the GABAB1a and GABAB1b subunit isoforms that solely differ in their ectodomains by a pair of sushi repeats that is unique to GABAB1a. Using a combined genetic, physiological, and morphological approach, we now demonstrate that GABAB1 isoforms localize to distinct synaptic sites and convey separate functions in vivo. At hippocampal CA3-to-CA1 synapses, GABAB1a assembles heteroreceptors inhibiting glutamate release, while predominantly GABAB1b mediates postsynaptic inhibition. Electron microscopy reveals a synaptic distribution of GABAB1 isoforms that agrees with the observed functional differences. Transfected CA3 neurons selectively express GABAB1a in distal axons, suggesting that the sushi repeats, a conserved protein interaction motif, specify heteroreceptor localization. The constitutive absence of GABAB1a but not GABAB1b results in impaired synaptic plasticity and hippocampus-dependent memory, emphasizing molecular differences in synaptic GABAB functions."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2006.04.014"xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Muller M."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Barbieri S."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Lujan R."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Zhang Y.P."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Bettler B."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Biermann B."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Vigot R."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Shigemoto R."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Oertner T.G."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Sansig G."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Fritschy J.M."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Gassmann M."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Kaupmann K."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Turecek R."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Brauner-Osborne H."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Jacobson L.H."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Cryan J.F."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Vacher C.M."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/author | "Guetg N."xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/16701209 | http://purl.uniprot.org/core/pages | "589-601"xsd:string |