| http://purl.uniprot.org/citations/16702235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16702235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16702235 | http://www.w3.org/2000/01/rdf-schema#comment | "Titin, the largest protein known to date, has been linked to sarcomere assembly and function through its elastic adaptor and signaling domains. Titin's M-line region contains a unique kinase domain that has been proposed to regulate sarcomere assembly via its substrate titin cap (T-cap). In this study, we use a titin M line-deficient mouse to show that the initial assembly of the sarcomere does not depend on titin's M-line region or the phosphorylation of T-cap by the titin kinase. Rather, titin's M-line region is required to form a continuous titin filament and to provide mechanical stability of the embryonic sarcomere. Even without titin integrating into the M band, sarcomeres show proper spacing and alignment of Z discs and M bands but fail to grow laterally and ultimately disassemble. The comparison of disassembly in the developing and mature knockout sarcomere suggests diverse functions for titin's M line in embryonic development and the adult heart that not only involve the differential expression of titin isoforms but also of titin-binding proteins."xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200601014"xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200601014"xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/author | "Luo X."xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/author | "Luo X."xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/author | "Gotthardt M."xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/author | "Gotthardt M."xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/author | "Weinert S."xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/author | "Weinert S."xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/author | "Erdmann B."xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/author | "Erdmann B."xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/author | "Bergmann N."xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/author | "Bergmann N."xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/pages | "559-570"xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/pages | "559-570"xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/title | "M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere."xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/title | "M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere."xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/volume | "173"xsd:string |
| http://purl.uniprot.org/citations/16702235 | http://purl.uniprot.org/core/volume | "173"xsd:string |