| http://purl.uniprot.org/citations/16704373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16704373 | http://www.w3.org/2000/01/rdf-schema#comment | "The CBP [CREB (cAMP-response-element-binding protein)-binding protein]/p300 acetyltransferases function as transcriptional co-activators and play critical roles in cell differentiation and proliferation. Accumulating evidence shows that alterations of the CBP/p300 protein levels are linked to human tumours. In the present study, we show that the levels of the CBP/p300 co-activators are decreased dramatically by continuous PDGF (platelet-derived growth factor) and Ras signalling pathway activation in NIH 3T3 fibroblasts. This effect occurs by reducing the expression levels of the CBP/p300 genes. In addition, CBP and p300 are degraded by the 26 S proteasome pathway leading to an overall decrease in the levels of the CBP/p300 proteins. Furthermore, we provide evidence that Mdm2 (murine double minute 2), in the presence of active H-Ras or N-Ras, induces CBP/p300 degradation in NIH 3T3 cells. These findings support a novel mechanism for modulating other signalling transduction pathways that require these common co-activators."xsd:string |
| http://purl.uniprot.org/citations/16704373 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20060052"xsd:string |
| http://purl.uniprot.org/citations/16704373 | http://purl.uniprot.org/core/author | "Martinez-Balbas M.A."xsd:string |
| http://purl.uniprot.org/citations/16704373 | http://purl.uniprot.org/core/author | "Valls E."xsd:string |
| http://purl.uniprot.org/citations/16704373 | http://purl.uniprot.org/core/author | "Oliva J.L."xsd:string |
| http://purl.uniprot.org/citations/16704373 | http://purl.uniprot.org/core/author | "Rojas J.M."xsd:string |
| http://purl.uniprot.org/citations/16704373 | http://purl.uniprot.org/core/author | "Sanchez-Molina S."xsd:string |
| http://purl.uniprot.org/citations/16704373 | http://purl.uniprot.org/core/author | "Garcia-Vargas S."xsd:string |
| http://purl.uniprot.org/citations/16704373 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16704373 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/16704373 | http://purl.uniprot.org/core/pages | "215-224"xsd:string |
| http://purl.uniprot.org/citations/16704373 | http://purl.uniprot.org/core/title | "The histone acetyltransferases CBP/p300 are degraded in NIH 3T3 cells by activation of Ras signalling pathway."xsd:string |
| http://purl.uniprot.org/citations/16704373 | http://purl.uniprot.org/core/volume | "398"xsd:string |
| http://purl.uniprot.org/citations/16704373 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16704373 |
| http://purl.uniprot.org/citations/16704373 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16704373 |
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