| http://purl.uniprot.org/citations/16709933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16709933 | http://www.w3.org/2000/01/rdf-schema#comment | "CCAAT/enhancer binding protein beta (C/EBPbeta) is one of a 6-member family of C/EBPs. These transcription factors are involved in the regulation of various aspects of cellular growth and differentiation. Although C/EBPbeta has important functions in B- and T-cell differentiation, its expression has not been well studied in lymphoid tissues. We, therefore, analyzed its expression by immunohistochemistry and Western blot in normal lymphoid tissues and in 248 well-characterized lymphomas and lymphoma cell lines. Nonneoplastic lymphoid tissues and most B-cell, T-cell, and Hodgkin lymphomas lacked detectable levels of C/EBPbeta. In contrast, most (40 of 45; 88%) cases of ALK-positive anaplastic large cell lymphoma (ALCL) strongly expressed C/EBPbeta. Western blot analysis confirmed C/EBPbeta expression in the ALK-positive ALCLs and demonstrated elevated levels of the LIP isoform, which has been associated with increased proliferation and aggressiveness in carcinomas. Transfection of Ba/F3 and 32D cells with NPM-ALK and a kinase-inhibitable modified NPM-ALK resulted in the induction of C/EBPbeta and demonstrated dependence on NPM-ALK kinase activity. In conclusion, we report the constitutive expression of C/EBPbeta in ALK-positive ALCL and show its relationship to NPM-ALK. We suggest that C/EBPbeta is likely to play an important role in the pathogenesis and unique phenotype of this lymphoma."xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-10-014258"xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/author | "Duyster J."xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/author | "Martinez A."xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/author | "Raffeld M."xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/author | "Jaffe E.S."xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/author | "Pittaluga S."xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/author | "Miething C."xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/author | "Fend F."xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/author | "Quintanilla-Martinez L."xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/author | "Vivero A."xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/author | "Rudelius M."xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/author | "Anastasov N."xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/author | "Klier M."xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/author | "Davies-Hill T."xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/pages | "2029-2036"xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/title | "NPM-ALK-dependent expression of the transcription factor CCAAT/enhancer binding protein beta in ALK-positive anaplastic large cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/16709933 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16709933 |
| http://purl.uniprot.org/citations/16709933 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16709933 |
| http://purl.uniprot.org/uniprot/#_A0A0K2YUJ3-mappedCitation-16709933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16709933 |
| http://purl.uniprot.org/uniprot/#_A0A140VJQ2-mappedCitation-16709933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16709933 |