| http://purl.uniprot.org/citations/16710293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16710293 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphorylation of neural proteins in response to a diverse array of external stimuli is one of the main mechanisms underlying dynamic changes in neural circuitry. The NR2B subunit of the NMDA receptor is tyrosine-phosphorylated in the brain, with Tyr-1472 its major phosphorylation site. Here, we generate mice with a knockin mutation of the Tyr-1472 site to phenylalanine (Y1472F) and show that Tyr-1472 phosphorylation is essential for fear learning and amygdaloid synaptic plasticity. The knockin mice show impaired fear-related learning and reduced amygdaloid long-term potentiation. NMDA receptor-mediated CaMKII signaling is impaired in YF/YF mice. Electron microscopic analyses reveal that the Y1472F mutant of the NR2B subunit shows improper localization at synapses in the amygdala. We thus identify Tyr-1472 phosphorylation as a key mediator of fear learning and amygdaloid synaptic plasticity."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601156"xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Watanabe M."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Nakazawa T."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Fukaya M."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Goto J."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Ebine K."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Sudo K."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Tezuka T."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Manabe T."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Komai S."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Umemori H."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Kiyama Y."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Watabe A.M."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Horai R."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Delawary M."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/author | "Arima-Yoshida F."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/pages | "2867-2877"xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/title | "NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity."xsd:string |
| http://purl.uniprot.org/citations/16710293 | http://purl.uniprot.org/core/volume | "25"xsd:string |