| http://purl.uniprot.org/citations/16710474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16710474 | http://www.w3.org/2000/01/rdf-schema#comment | "Diabetes results from an absolute or relative reduction in pancreatic beta cell mass (BCM) leading to insufficient insulin secretion and hyperglycemia. Measurement of insulin secretory capacity is currently used as a surrogate measure of BCM. However, serum insulin concentrations provide an imprecise index of BCM, and no reliable noninvasive measure of BCM is currently available. Type 2 vesicular monoamine transporters (VMAT2) are expressed in human islet beta cells, as well as in tissues of the CNS. [11C]Dihydrotetrabenazine ([11C]DTBZ) binds specifically to VMAT2 and is a radioligand currently used in clinical imaging of the brain. Here we report the use of [11C]DTBZ to estimate BCM in a rodent model of spontaneous type 1 diabetes (the BB-DP rat). In longitudinal PET studies of the BB-DP rat, we found a significant decline in pancreatic uptake of [11C]DTBZ that anticipated the loss of glycemic control. Based on comparison of standardized uptake values (SUVs) of [11C]DTBZ and blood glucose concentrations, loss of more than 65% of the original SUV correlated significantly with the development of persistent hyperglycemia. These studies suggest that PET-based quantitation of VMAT2 receptors provides a noninvasive measurement of BCM that could be used to study the pathogenesis of diabetes and to monitor therapeutic interventions."xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci27645"xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/author | "Mann J.J."xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/author | "Harris P.E."xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/author | "Hardy M."xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/author | "Simpson N."xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/author | "Leibel R."xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/author | "Maffei A."xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/author | "Souza F."xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/author | "Raffo A."xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/author | "Goland R."xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/author | "Kilbourn M."xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/author | "Saxena C."xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/author | "Van Heertum R."xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/pages | "1506-1513"xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/title | "Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model."xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/16710474 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16710474 |
| http://purl.uniprot.org/citations/16710474 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16710474 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JSJ6-mappedCitation-16710474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16710474 |
| http://purl.uniprot.org/uniprot/#_Q01827-mappedCitation-16710474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16710474 |
| http://purl.uniprot.org/uniprot/Q01827 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16710474 |