| http://purl.uniprot.org/citations/16713561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16713561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16713561 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the CYLD gene cause tumors of hair-follicle keratinocytes. The CYLD gene encodes a deubiquitinase that removes lysine 63-linked ubiquitin chains from TRAF2 and inhibits p65/p50 NF-kappaB activation. Here we show that mice lacking Cyld are highly susceptible to chemically induced skin tumors. Cyld-/-tumors and keratinocytes treated with 12-O-tetradecanoylphorbol-13 acetate (TPA) or UV light are hyperproliferative and have elevated cyclin D1 levels. The cyclin D1 elevation is caused not by increased p65/p50 action but rather by increased nuclear activity of Bcl-3-associated NF-kappaB p50 and p52. In Cyld+/+ keratinocytes, TPA or UV light triggers the translocation of Cyld from the cytoplasm to the perinuclear region, where Cyld binds and deubiquitinates Bcl-3, thereby preventing nuclear accumulation of Bcl-3 and p50/Bcl-3- or p52/Bcl-3-dependent proliferation. These data indicate that, depending on the external signals, Cyld can negatively regulate different NF-kappaB pathways; inactivation of TRAF2 controls survival and inflammation, while inhibition of Bcl-3 controls proliferation and tumor growth."xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.03.041"xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.03.041"xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/author | "Pfeifer A."xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/author | "Pfeifer A."xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/author | "Chmielarska K."xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/author | "Chmielarska K."xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/author | "Fassler R."xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/author | "Fassler R."xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/author | "Hennecke K."xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/author | "Hennecke K."xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/author | "Massoumi R."xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/author | "Massoumi R."xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/pages | "665-677"xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/pages | "665-677"xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/title | "Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling."xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/title | "Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling."xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/16713561 | http://purl.uniprot.org/core/volume | "125"xsd:string |