| http://purl.uniprot.org/citations/16713580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16713580 | http://www.w3.org/2000/01/rdf-schema#comment | "S(N)1-type alkylating agents that produce cytotoxic O(6)-methyl-G (O(6)-meG) DNA adducts induce cell cycle arrest and apoptosis in a manner requiring the DNA mismatch repair (MMR) proteins MutSalpha and MutLalpha. Here, we show that checkpoint signaling in response to DNA methylation occurs during S phase and requires DNA replication that gives rise to O(6)-meG/T mispairs. DNA binding studies reveal that MutSalpha specifically recognizes O(6)-meG/T mispairs, but not O(6)-meG/C. In an in vitro assay, ATR-ATRIP, but not RPA, is preferentially recruited to O(6)-meG/T mismatches in a MutSalpha- and MutLalpha-dependent manner. Furthermore, ATR kinase is activated to phosphorylate Chk1 in the presence of O(6)-meG/T mispairs and MMR proteins. These results suggest that MMR proteins can act as direct sensors of methylation damage and help recruit ATR-ATRIP to sites of cytotoxic O(6)-meG adducts to initiate ATR checkpoint signaling."xsd:string |
| http://purl.uniprot.org/citations/16713580 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2006.04.023"xsd:string |
| http://purl.uniprot.org/citations/16713580 | http://purl.uniprot.org/core/author | "Hsieh P."xsd:string |
| http://purl.uniprot.org/citations/16713580 | http://purl.uniprot.org/core/author | "Yoshioka K."xsd:string |
| http://purl.uniprot.org/citations/16713580 | http://purl.uniprot.org/core/author | "Yoshioka Y."xsd:string |
| http://purl.uniprot.org/citations/16713580 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16713580 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/16713580 | http://purl.uniprot.org/core/pages | "501-510"xsd:string |
| http://purl.uniprot.org/citations/16713580 | http://purl.uniprot.org/core/title | "ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts."xsd:string |
| http://purl.uniprot.org/citations/16713580 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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