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| http://purl.uniprot.org/citations/16713741 | http://www.w3.org/2000/01/rdf-schema#comment | "To determine the respective role of the IL-12 and IL-4 pathways in the pathogenesis of systemic lupus erythematosus, we bred the Stat4 and Stat6 null alleles onto the lupus-prone mouse B6.TC, which is a congenic derivative of NZM2410. This model is characterized by abnormal splenocyte expansion, distribution and architecture, T cell activation, peripheral B cell development, production of anti-nuclear antibodies, and proliferative glomerulonephritis. STAT4 deficiency normalized the expression of each of these disease markers toward or to C57BL/6 levels. In contrast, STAT6 deficiency impacted splenocyte expansion and architecture, T cell activation, and anti-nuclear autoantibody production, but without any significant effect on B cell development or renal pathology. These results show that the IL-12/STAT4 pathway is involved in multiple disease-associated phenotypes in the B6.TC mouse. In contrast, the IL-4/STAT6 pathway regulates only a subset of disease markers that did not affect renal pathology."xsd:string |
| http://purl.uniprot.org/citations/16713741 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.clim.2006.03.009"xsd:string |
| http://purl.uniprot.org/citations/16713741 | http://purl.uniprot.org/core/author | "Xu Z."xsd:string |
| http://purl.uniprot.org/citations/16713741 | http://purl.uniprot.org/core/author | "Duan B."xsd:string |
| http://purl.uniprot.org/citations/16713741 | http://purl.uniprot.org/core/author | "Morel L."xsd:string |
| http://purl.uniprot.org/citations/16713741 | http://purl.uniprot.org/core/author | "Croker B.P."xsd:string |
| http://purl.uniprot.org/citations/16713741 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16713741 | http://purl.uniprot.org/core/name | "Clin Immunol"xsd:string |
| http://purl.uniprot.org/citations/16713741 | http://purl.uniprot.org/core/pages | "189-198"xsd:string |
| http://purl.uniprot.org/citations/16713741 | http://purl.uniprot.org/core/title | "STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus."xsd:string |
| http://purl.uniprot.org/citations/16713741 | http://purl.uniprot.org/core/volume | "120"xsd:string |
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