| http://purl.uniprot.org/citations/16714073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16714073 | http://www.w3.org/2000/01/rdf-schema#comment | "We studied the association between class II human leukocyte antigen (HLA)-DRB1*0301 presented measles virus (MV) peptide-specific cytokine responses and DQB1 and DPB1 alleles among 313 individuals who received two doses of measles-mumps-rubella-II vaccine. The overall median IFN-gamma secretion levels (first and third quartiles) for the 19-amino acid MV phosphoprotein (MV-P)- and 14-amino acid MV nucleoprotein (MV-N)-derived peptides were 27.7 pg/ml (1.8, 109.4) and 1.9 pg/ml (-6.2, 13.0), respectively; median IL-4 secretion levels were -0.6 pg/ml (-7.1, 6.2) and 2.4 pg/ml (-3.2, 9.3), respectively. Primary statistical analyses were adjusted for previously identified DRB1 associations. A marginally significant increase in the frequency of the DQB1*0604 (p=0.02) allele was found among subjects who demonstrated detectable IL-4 levels to the MV-P peptide. Further, DPB1*0201 (p=0.02) and DPB1*1301 (p=0.09) alleles provided suggestive evidence of an association with MV-P-induced IL-4 secretion. Examination of IFN-gamma responses to MV-P and MV-N indicated that none of the individual alleles of the DQB1 and DPB1 loci were associated with peptide-induced T cell response. An increase in the frequency of DPB1*0501 (p=0.01) was found among subjects who failed to produce MV-N peptide-specific IL-4 responses. These data further confirm that HLA-DRB1 alleles are the major restriction molecules for MV-P and MV-N measles virus antigen presentation to T cells. We speculate that MV-P and MV-N peptides derived from DRB1*0301 could potentially be recognized in association with different HLA molecules, including DQB1 and DPB1; however, statistical adjustments for the effect of HLA-DR locus could potentially alter these genetic relationships. This concept provides important information supporting the use of promiscuous peptides in a peptide-based vaccine approach."xsd:string |
| http://purl.uniprot.org/citations/16714073 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.vaccine.2006.04.034"xsd:string |
| http://purl.uniprot.org/citations/16714073 | http://purl.uniprot.org/core/author | "Ovsyannikova I.G."xsd:string |
| http://purl.uniprot.org/citations/16714073 | http://purl.uniprot.org/core/author | "Poland G.A."xsd:string |
| http://purl.uniprot.org/citations/16714073 | http://purl.uniprot.org/core/author | "Vierkant R.A."xsd:string |
| http://purl.uniprot.org/citations/16714073 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16714073 | http://purl.uniprot.org/core/name | "Vaccine"xsd:string |
| http://purl.uniprot.org/citations/16714073 | http://purl.uniprot.org/core/pages | "5381-5389"xsd:string |
| http://purl.uniprot.org/citations/16714073 | http://purl.uniprot.org/core/title | "Importance of HLA-DQ and HLA-DP polymorphisms in cytokine responses to naturally processed HLA-DR-derived measles virus peptides."xsd:string |
| http://purl.uniprot.org/citations/16714073 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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