| http://purl.uniprot.org/citations/16714294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16714294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16714294 | http://www.w3.org/2000/01/rdf-schema#comment | "Polycomb group proteins Bmi-1 and Ring1B are core subunits of the PRC1 complex, which plays important roles in the regulation of Hox gene expression, X-chromosome inactivation, tumorigenesis, and stem cell self-renewal. The RING finger protein Ring1B is an E3 ligase that participates in the ubiquitination of lysine 119 of histone H2A, and the binding of Bmi-1 stimulates the E3 ligase activity. We have mapped the regions of Bmi-1 and Ring1B required for efficient ubiquitin transfer and determined a 2.5-A structure of the Bmi-1-Ring1B core domain complex. The structure reveals that Ring1B "hugs" Bmi-1 through extensive RING domain contacts and its N-terminal tail wraps around Bmi-1. The two regions of interaction have a synergistic effect on the E3 ligase activity. Our analyses suggest a model where the Bmi-1-Ring1B complex stabilizes the interaction between the E2 enzyme and the nucleosomal substrate to allow efficient ubiquitin transfer."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m602461200"xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m602461200"xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/author | "Cao R."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/author | "Cao R."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/author | "Xu R.M."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/author | "Xu R.M."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/author | "Myers M.P."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/author | "Myers M.P."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/pages | "20643-20649"xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/pages | "20643-20649"xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/title | "Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex."xsd:string |
| http://purl.uniprot.org/citations/16714294 | http://purl.uniprot.org/core/title | "Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex."xsd:string |