| http://purl.uniprot.org/citations/16715089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16715089 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we investigated the potential role of bone-resorbing osteoclasts in homeostasis and stress-induced mobilization of hematopoietic progenitors. Different stress situations induced activity of osteoclasts (OCLs) along the stem cell-rich endosteum region of bone, secretion of proteolytic enzymes and mobilization of progenitors. Specific stimulation of OCLs with RANKL recruited mainly immature progenitors to the circulation in a CXCR4- and MMP-9-dependent manner; however, RANKL did not induce mobilization in young female PTPepsilon-knockout mice with defective OCL bone adhesion and resorption. Inhibition of OCLs with calcitonin reduced progenitor egress in homeostasis, G-CSF mobilization and stress situations. RANKL-stimulated bone-resorbing OCLs also reduced the stem cell niche components SDF-1, stem cell factor (SCF) and osteopontin along the endosteum, which was associated with progenitor mobilization. Finally, the major bone-resorbing proteinase, cathepsin K, also cleaved SDF-1 and SCF. Our findings indicate involvement of OCLs in selective progenitor recruitment as part of homeostasis and host defense, linking bone remodeling with regulation of hematopoiesis."xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm1417"xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/author | "Dar A."xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/author | "Lapidot T."xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/author | "Spiegel A."xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/author | "Kollet O."xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/author | "Elson A."xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/author | "Goichberg P."xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/author | "Sztainberg Y."xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/author | "Shivtiel S."xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/author | "Kalinkovich A."xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/author | "Lapid K."xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/author | "Samstein R.M."xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/author | "Tesio M."xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/pages | "657-664"xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/title | "Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells."xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/16715089 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16715089 |
| http://purl.uniprot.org/citations/16715089 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16715089 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRH2-mappedCitation-16715089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16715089 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRT6-mappedCitation-16715089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16715089 |
| http://purl.uniprot.org/uniprot/#_Q05CJ9-mappedCitation-16715089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16715089 |