| http://purl.uniprot.org/citations/16720699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16720699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16720699 | http://www.w3.org/2000/01/rdf-schema#comment | "Pathogen recognition by Toll-like receptors (TLRs) initiates innate immune responses that are essential for inhibiting pathogen dissemination and for the development of acquired immunity. The TLRs recognize pathogens with their N-terminal ectodomains (ECD), but the molecular basis for this recognition is not known. Recently we reported the x-ray structure for unliganded TLR3-ECD; however, it has proven difficult to obtain a crystal structure of TLR3 with its ligand, dsRNA. We have now located the TLR3 ligand binding site by mutational analysis. More than 50 single-residue mutations have been generated throughout the TLR3-ECD, but only two, H539E and N541A, resulted in the loss of TLR3 activation and ligand binding functions. These mutations locate the dsRNA binding site on the glycan-free, lateral surface of TLR3 toward the C terminus and suggest a model for dsRNA binding and TLR3 activation."xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0603245103"xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0603245103"xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/author | "Hall P.R."xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/author | "Hall P.R."xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/author | "Davies D.R."xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/author | "Davies D.R."xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/author | "Bell J.K."xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/author | "Bell J.K."xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/author | "Segal D.M."xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/author | "Segal D.M."xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/author | "Askins J."xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/author | "Askins J."xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/pages | "8792-8797"xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/pages | "8792-8797"xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/title | "The dsRNA binding site of human Toll-like receptor 3."xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/title | "The dsRNA binding site of human Toll-like receptor 3."xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/16720699 | http://purl.uniprot.org/core/volume | "103"xsd:string |