| http://purl.uniprot.org/citations/1672265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1672265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1672265 | http://www.w3.org/2000/01/rdf-schema#comment | "We isolated a cDNA encoding a functional human thrombin receptor by direct expression cloning in Xenopus oocytes. mRNA encoding this receptor was detected in human platelets and vascular endothelial cells. The deduced amino acid sequence revealed a new member of the seven transmembrane domain receptor family with a large amino-terminal extracellular extension containing a remarkable feature. A putative thrombin cleavage site (LDPR/S) resembling the activation cleavage site in the zymogen protein C (LDPR/I) was noted 41 amino acids carboxyl to the receptor's start methionine. A peptide mimicking the new amino terminus created by cleavage at R41 was a potent agonist for both thrombin receptor activation and platelet activation. "Uncleavable" mutant thrombin receptors failed to respond to thrombin but were responsive to the new amino-terminal peptide. These data reveal a novel signaling mechanism in which thrombin cleaves its receptor's amino-terminal extension to create a new receptor amino terminus that functions as a tethered ligand and activates the receptor."xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(91)90261-v"xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(91)90261-v"xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/author | "Hung D.T."xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/author | "Hung D.T."xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/author | "Coughlin S.R."xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/author | "Coughlin S.R."xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/author | "Vu T.-K.H."xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/author | "Vu T.-K.H."xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/author | "Wheaton V.I."xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/author | "Wheaton V.I."xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/pages | "1057-1068"xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/pages | "1057-1068"xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/title | "Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation."xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/title | "Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation."xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/1672265 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1672265 |
| http://purl.uniprot.org/citations/1672265 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1672265 |